CEBP/α increases functional β-cell mass

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Ray, Jason CEBP/α increases functional β-cell mass Faculty Mentor: Jeffery Tessem, Department of NDFS Introduction Type 1 and Type 2 diabetes are major global health concerns. Diabetes is characterized by impaired management of glucose in the bloodstream, which is due to decreased pancreatic functional β-cell mass. Functional β-cell mass is determined from the insulin secretion […]

Effects of nixtamalization on maize processing in Malawi

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Cooper, Annica Effects of nixtamalization on maize processing in Malawi Faculty Mentor: Frost Steele; Nutrition, Dietetics, and Food Science Introduction Malawi is a small country in southeastern Africa. The main crops that rural Malawians grow for food are maize, legumes, and dark, leafy greens. Due to this restrictive diet, many Malawians are at risk for […]

Is HDAC1 mediated β-cell proliferation dependent on decreased p15 expression?

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Hobson, Amanda Is HDAC1 mediated β-cell proliferation dependent on decreased p15 expression? Faculty Mentor: Jeffrey Tessem, Nutrition, Dietetics, and Food Science Introduction The body maintains normoglycemia through pancreatic β-cells which sense elevation in circulating glucose levels and secrete insulin to maintain the correct blood glucose concentration. A decrease in functional pancreatic β-cell mass leads to […]

Determining the Mechanism of Cocoa-Derived Epicatechin Enhancement of Glucose Stimulated Insulin Secretion

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Benjamin Bitner, and Jeffery Tessem; Department of Nutrition, Dietetics, Food Science Introduction Due to recent increases in incidence, diabetes is now classified as a global epidemic. Diabetes results from the eventual destruction of β-cell mass, which causes decreased insulin secretion. Increasing functional β-cell mass may provide a cure for diabetes. A previous study has shown […]

Identifying the Upstream Target of Resveratrol in Breast Cancer Cells

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Jeffrey Mecham and Jason Kenealey; Department of Nutrition, Dietetics, & Food Science Introduction One commonly disrupted pathway in many different cancer cells lines revolves around the tumor suppressor protein p53. Approximately half of human cancers exhibit direct, inactivating mutations of p53, while the majority of the remainder either elevate inhibitors, reduce activators, or deactivate downstream targets […]

The role of CDK5R1 in β-­cell survival from apoptosis

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Amanda Hobson and Jeffrey Tessem, Nutrition, Dietetics, and Food Science Introduction Type 1 and Type 2 diabetes are classified as a decrease in functional ß-cell mass, which results in impaired blood glucose regulation. Functional ß-cell mass is defined as the glucose stimulated insulin secretion rate multiplied by the total cellular mass which is determined by […]

Determining if c-Fos protects β-cells from Apoptosis

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Kyle Kener and Jeffery Tessem, Nutrition, Dietetics, and Food Science Diabetes, a disease characterized by the inability of the body to maintain a normal blood glucose level, continues to affect the lives of many. In both Type I and Type II diabetes, eventual β-cell destruction results in decreased β-cell mass. Regeneration of functional β-cells and […]

The Role Of Palmitate in Upregulating Nr4a1 and Nr4a3 Proposal Status

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Jordan Tingey and Jeffery Tessem, Nutrition, Dietetics, and Food Science This project focused on the effects of palmitate on transcription factors, Nr4a1 and Nr4a3. All experiments were preformed on a beta cell line. The first experiment was done to show if palmitate effected proliferation of Nr4a1 and Nr4a3 knockout cell lines. This experiment was preformed […]

The role of HDAC1 in increasing β-cell glucose stimulated insulin secretion and apoptosis resistance

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Carrie Draney and Jeffrey Tessem, Nutrition, Dietetics and Food Science Introduction Type 1 and type 2 diabetes affects more than 9% of the American population and the incidences of diabetes continue to increase at a startling rate. Both Type 1 and Type 2 diabetes impede β- cell function (insulin secretion) by destroying β-cell mass. Increasing […]