John Kauwe, Biology Project Justification and Overview Successful enrollment in and completion of graduate programs requires a constellation of skills. Students must be prepared to plan and execute experiments, present their findings both verbally and in manuscript form and interact effectively with senior scientists in the field of their choice. In this MEG I will […]
RAGE and SAGE: Therapeutic Modalities for COPD
Paul Reynolds, Physiology and Developmental Biology Academic Objectives Met and Results Observed Funding available through this MEG award has provided an opportunity for me to meet many academic objectives I’ve determined to be important at BYU. We have been successful in conducting pilot studies that reveal possible roles for SAGEs in ameliorating mechanisms of lung […]
A Race Against Time: Deciphering Evolution and Describing New Species of Threatened Tropical Stick Insects (Phasmatodea)
Michael F. Whiting, Biology Funding was received in 2016 to support mentored research into the phylogeny and evolution of stick insects. Specific goals include providing students with scientific design experience, field-based research experience, collections-based experience, molecular lab experience, bioinformatics experience, and experience in presentation at national meetings and publication in peer reviewed journals. One particular […]
T Cell Immunotherapy of Infection Disease and Cancer
Scott Weber, Microbiology and Molecular Biology 1) Project Summary This project was focused on improving the immune response to infectious disease and cancer. We have engineered T cell receptors with 1000-fold increase in affinity and will characterize their value as diagnostics and therapeutics. In addition, we examined changes in T cell function due to the […]
Development of Real-Time Polymerase Chain Reaction (q-PCR) Assays for the Detection and Identification of Drug-resistance Genes in Carbapenem-resistant Enterobacteriaceae (CRE)
Richard A. Robison, Ph.D., Microbiology and Molecular Biology I. The Specific aims for the project were as follows: Develop q-PCR assays for the various carbapenem-resistance genes, such as KPC, IMP, VIM, and NDM-1, and then multiplex them into single assays that can be used to quickly characterize an isolate. II. Accomplishments to date related to […]
Increasing the Accuracy of Molecular Biomarkers via Evidence-based Algorithm Selection
Stephen R. Piccolo, Biology This is a final report for a Mentoring Environment Grant that Brigham Young University awarded to me in 2016. Below is a summary of the project that this grant enabled students in my research lab to perform, as well as information about how the funds were used. Research Project In making […]
Combating Obesity Through Gut Microbiome Targeted Bacteriophage Therapy
Gongze Zhao, Dr. Laura Bridgewater, Micro & Molecular Biology Introduction The human gut consists of approximately 1.5 kg of bacteria, and 50% of the biomass in our fecal matter is bacterial cells (Nicholson, 2005). Diet is a major factor in shaping the composition of the gut microbiota, (Zhang, 2010) which in turn influences the body by […]
The Role of Nr4a1 in β-cell Growth and Onset of Type 2 Diabetes
Adam Wynn, Jeffery Tessem, Ph.D. Nutrition, Dietetics, and Food Science Progression to type 2 diabetes (T2D) includes a loss of functional pancreatic beta cells (β-cells), which are responsible for secreting insulin and maintaining healthy blood sugar levels. Nr4a1 is a gene that has been shown to be involved in fuel utilization in the liver, muscles, and […]
The Role of Nrf2 In Prevention of Oxidative Stress Caused by Valproic Acid
Madison Wilson and Jason M. Hansen, Physiology & Developmental Biology Introduction Valproic acid (VPA) is a common drug used to treat epileptic seizures as well as bipolar disease. Over the past decade, the use of these drugs has increased dramatically as they are now being prescribed as antipsychotics, mood stabilizers, and are currently being tested […]
Chemokine Receptor CCBP2-V41A and its Role in Inflammation and Alzheimer’s Disease
Allen Weinert and Scott Weber, Microbiology & Molecular Biology Introduction The leading cause of dementia in elderly patients is Alzheimer’s disease (AD), a degenerating and fatal neurodegenerative condition. AD is a proteopathic disease caused by extensive accumulation of amyloid beta plaques and neurofibrillary tangles. A recent genomewide association study analyzing 59 AD-associated cerebrospinal fluid (CSF) […]
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