Eric Bready and Dr. Merritt Andrus, Department of Chemistry and Biochemistry The purpose of this project was completion of the total organic synthesis of the anti-cancer compound (S)-equol. My goal was to carry out our planned synthesis of this molecule using Phase Transfer Catalysts, (PTCs), which promote the formation of the S enantiomer as opposed […]
Search Results for: synthesis
Mentoring Undergraduates Via Organic Synthesis
Steven L. Castle, Department of Chemistry and Biochemistry Introduction This report summarizes the results of the mentoring environment in my laboratory that were generated from January 2012 to present. During this period, a total of seven undergraduates performed research in my laboratory. Their names and accomplishments are listed below. Evaluation of Academic Objectives Our academic […]
Synthesis Of Bioconjugate Dimers Used To Probe The Structure Of PGlycoprotein
Emily Parker and Dr. Merritt B. Andrus, Chemistry and Biochemistry Chemotherapy is one of the primary treatments for cancer today. A patient’s life may depend on its efficacy, so when he or she develops multi-drug resistance (MDR) the results can be devastating. MDR, a clinical condition manifested by the failure of chemotherapy, is primarily due […]
Independent Murine Biosynthesis of Threonine: Expression of a Complete Bacterial Biosynthetic Pathway in Mice
Ryan D. McAllister and Dr. David Kooyman, Animal Science Threonine is one of the 20 common amino acids found in nature. It is a limiting factor for the growth of many non-ruminant animals such as swine and mice and must be obtained from their diet. When threonine is absent from the diet of these animals, […]
SYNTHESIS OF A POTENTIAL PHOTOAFFINITY LABELING AGENT, 4-NITR0-3- TRINUOROMETHYLBENZYL PHENYL SULFIDE
Christina Johnson and Dr. Steve Fleming, Department of Chemistry and Biochemistry Introduction Photoaffinity labeling is a useful methodology for determining the active site of a given enzyme. It is also a very important tool in discovering what roles different enzymes play in the human body. Our research group has been involved in a continuous effort […]
THE SYNTHESIS OF NOVEL CHIRAL PYRIDINO CROWN ETHERS
Steven L. Castle, Department of Chemistry Introduction 0ur research group has been interested in the synthesis of chiral pyridino crown ethers for some time. Many chiral pyridino crown ethers have been shown to exhibit enantiomeric recognition for chiral ammonium salts.1 In other words, the crown compound forms a more stable complex with one enantlomer of […]
Report of Progression on The Synthesis of a Conformational Amphiphile for Nondestructive Diffusion Through Membrane Bilayers
Paul B. Savage and Dr. David B. McMullin, Chemistry and Biochemistry The stability of all cellular life in the presence of adverse environmental conditions may be attributed to the function of cellular membranes. Membranes are unique in their ability to act as barriers with selective permeability (1). Such selective permeability allows cells to control and […]
A Partial Asymmetric Synthesis of the Anti-tumor Antibiotic Geldanamycin
Bryon Simmons and Dr. Merritt B. Andrus, Chemistry and Biochemistry Geldanamycin, a member of the benzoquinoid ansamycin family, was discovered in 1970 by workers at UpJohn laboratories.1 Scientists were eager to characterize and assess the biological activity of this natural product, first isolated from the bacteria species Steptomyces hygroscpius.2 It was soon learned that geldanamycin […]
Synthesis of Systematically Varied Nucleosides as a Logical Approach Toward Inhibitor Design for Nucleoside Transport Proteins
Lars P.C. Nielsen and Dr. Morris J. Robins, Chemistry and Biochemistry Glucose transporter proteins constitute one class of transmembrane integral proteins that have received much attention in the current chemical literature. Many prominent groups have set out to explore their mechanisms, kinetics, and active sites. Studies have focussed on one of these in particular, Human […]
Mechanistic Study of Cholic Acid-Derived Antibiotics Synthesis and Electron Microscopic Analysis
Katie L Jensen and Dr. Paul B Savage, Chemistry and Biochemistry Pathogenic bacterial resistance to antibiotics has risen sharply over the past two decades.1 This problem is compounded with Gram-negative bacteria, which, in addition to developing specific resistant mechanisms, also display membrane structures that are impermeable to many hydrophobic antibiotics. Thus, new antibiotics are needed […]
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