Brian Earley and Dr. Laura Bridgewater, Department of Microbiology and Molecular Biology Bmp2 is a secretory mammalian protein that plays important roles in bone development and adult pathology. Recently, a nuclear variant (nBmp2) was discovered with an unknown function for this typically secretory protein in the nucleus (Felin et al., 2010). The purpose of this […]
Search Results for: protein
Validation of Possible Blood Serum Biomarkers Linked to Genetic Risk of Alzheimer’s Disease
Jesse Cobell and Dr. John Kauwe, Department of Biology Importance of the Project In 2011, the Alzheimer’s Association released in their annual facts and figures that 5.4 million people suffer from Alzheimer’s disease. Alzheimer’s is the sixth leading cause of death in the United States and is the only disease in the top ten that […]
Ex Vivo Infection and Re‐isolation of Human Herpesvirus 6
Stephanie Carlson and Dr. Bradford Berges, Department of Microbiology and Molecular Biology Science rarely cooperates as anticipated, but that can often lead to unexpected insight and solution. I ran into that this semester with a certain aspect of our project. We are continuing to collect data for the American Society for Virology in late July […]
MDCK Gene Expression During EMT
Jason Burton and Professor Marc Hansen, Department of Physiology and Developmental Biology Cancer is one of the leading causes of death in the United States. This is mostly due to a lack of understanding into the function of cancer and the different mechanisms it uses to spread. The process by which cancer cells detach from the […]
Genomic and Proteomic Analysis of an Erwinia amylovora Phage
Alicia Brighton and Dr. Julianne Grose, Department of Microbiology and Molecular Biology Introduction Fireblight is a disease, caused by the bacteria Erwinia amylovora, that can infect some fruit trees, including apple and pear trees. When an infection occurs, the effects can be devastating—any infected part of the tree must be removed and destroyed, sometimes resulting […]
Scaffold Design of a Novel Nano-Particle for Single-Target Imaging
Chad Varner and Dr. Brad Bundy, Department of Chemical Engineering The purpose of this project has been to help develop a novel nano-imaging particle. Current methodologies have limitations that preclude them from being used for nanometric (1-500nm) imaging processes in living organisms. These include, but are not limited to, low signal to noise ratios, limited […]
Silver Flash: A MEMs Memory Device
John Stout and Dr. Aaron Hawkins, Department of Electrical Engineering The silver flash project is an effort to create a reliable, MEMs based memory device. As a joint electrical and mechanical structure these devices offer several advantages over the traditional NAND flash memory currently found in phones, mp3 players, and USB memory drives. The silver […]
The Role of PAS-kinase In Skeletal Muscle Hypertrophy and Endurance Adaptation
Dr. David Thomson, Department of Physiology & Developmental Biology Evaluation of academic objectives and project findings The purpose of this mentoring environment grant was to determine whether the presence of the protein PAS-kinase (PASK) affects muscle growth and/or endurance performance. Our primary model system was the PASK knockout mouse (PASK-KO) and findings from this mouse […]
Secretory phospholipase A2
Dr. John Bell, Department of Physiology & Developmental Biology Abstract of original proposal Secretory phospholipase A2 (sPLA2) binds to and hydrolyzes cell membranes. It is important in inflammatory responses and diseases including septic shock, atherosclerosis, and cancer. Normally, cells resist the enzyme’s action, but they become susceptible early during the process of either biochemically-programmed or […]
Co-amplification of Mitochondrial Pseudogenes
Dr. Michael Whiting, Department of Biology Funding was received from the BYU ORCA mentorship program during 2011 to support undergraduates performing research in my lab, under the mentorship of postdoctoral researchers, graduate students, and myself. During 2011, this funding provided direct support for 6 undergraduates who are in various stages of completing research projects. The […]