Background and Significance Neofunctionalization is the process by which genes gain a new or modified function as a result of gene duplication and modification of one or more of the new genes. This exciting area of research helps explain the diversification of protein functions in cells. The number of documented examples has increased in recent […]
Search Results for: protein
Role of the Viral LANA Protein in Human Cancers caused by Kaposi’s Sarcoma-Associated Herpesvirus
Gregory Low and Brad Berges, Microbiology and Molecular Biology The purpose of our experiment was to ascertain the importance of the LANA protein encoded by the Kaposi’s Sarcoma-Associated Herpesvirus (KSHV). LANA is believed to be essential for the survival of KSHV in human cells. KSHV causes a variety of cancers including Kaposi’s sarcoma (KS), multicentric […]
Novel G-protein Coupled Receptor Expression and Modulation of Synaptic Plasticity
Michael Thayer Christensen and Dr. Jeff Edwards, Physiology and Developmental Biology Introduction According to the Centers for Disease Control and Prevention, Alzheimer’s disease – infamously known for its patients’ loss of memory and other intellectual abilities – is the sixth most common cause of death in the United States. Sadly this is just one of […]
Confirming the spatial relationship between iron, tau protein, and amyloid beta within the subiculum as a means to better detect Alzheimer’s disease with Magnetic Resonance Imaging
Brandon Herrington and Jonathan Wisco, Department of Physiology and Developmental Biology Introduction As the 6th leading cause of death in the United States1, and because of the significant deterioration it causes in the quality of life of its victims, Alzheimer’s disease is an area where research to improve its early diagnosis is paramount to establishing […]
Identification of the Function of a Unique B4 Mycobacteriophage Protein via in silico and in vivo Analysis
Cameron Sargent and Dr. Julianne Grose, Microbiology and Molecular Biology Introduction Once the leading cause of death in the United States, tuberculosis still burdens the world as the second deadliest infectious disease worldwide, latently infecting one-third of the world population and causing 1.5 million deaths in 2013 [1]. Tuberculosis is particularly lethal largely because the […]
The use of mass defect to measure protein turnover in vivo
Elise Wilson and Faculty Mentor: John C. Price, Department of Chemistry and Biochemistry Introduction Mass spectrometry utilizes ionized atoms or molecules, and separates these particles according to their mass-to-charge (m/z) ratios. Mass spectrometry is a commonly used analytical tool in physics, chemistry, biochemistry, and pharmaceutical science.1 In the biochemical study of protein kinetics, mass spectrometry […]
Do Differently Managed Dairy Cows with Production-related Metabolic Diseases have Similar Protein and Fat Species in Colostrum and Milk?
Holly Martin and Dr. Beverly Roeder, Biology Introduction Production-related metabolic diseases (PRMDs) in dairy cows threaten the livelihood of the animals as well as the productivity and success of the dairy industry. Because dairy cows supply an important food source for humans, understanding, managing, and preventing these diseases protects this source. Management and prevention of […]
Determining the spatial relationship between iron, tau protein, and amyloid beta within the subiculum as a means to better detect Alzheimer’s disease
Brandon Herrington and Jonathan Wisco, Department of Physiology and Developmental Biology Introduction As the 6th leading cause of death in the United States1, and because of the significant deterioration it causes in the quality of life of its victims, Alzheimer’s disease is an area where research to improve its early diagnosis is paramount to establishing […]
Elucidating a Precise Role for the Small Heat Shock Proteins CryAB and HspB2 in Cardiac Robustness
Julianne H Grose, Microbiology and Molecular Biology Evaluation of how well the academic objectives of the proposal were met Specific Aim 1: Perform yeast two-hybrid screens on wild type CryAB, R120G CryAB, and HspB2 in order to create a protein-protein interaction network and identify potential substrates. Achievements: Large-scale yeast-two hybrid screens were performed on wild […]
Structure of the PhLP1-Gβ-CCT Complex Reveals a Molecular Mechanism for Gprotein β Subunit Folding and βγ Dimer Assembly
Devon Blake and Dr. Barry Willardson, Chemistry and Biochemistry Introduction and Project Importance Cells detect and respond to a myriad of extracellular signals via seven-transmembrane G protein-coupled receptors and their associated G protein signaling pathways. The pathway is initiated by the binding of a signaling molecule, such as a hormone or neurotransmitter, to its binding […]
- « Previous Page
- 1
- 2
- 3
- 4
- …
- 68
- Next Page »