Max Olivier and Luke Howard, School of Music A few years ago, I happened upon a little-known recording of the cello concerto of 20th-century Turkish composer Ahmed Adnan Saygun (1907-1991), and I immediately knew that I had discovered a gem. From the opening bars, Saygun drew me into his unique soundworld and captured my attention. […]
Search Results for: dna
Cell Free Single Stranded DNA Concentration in CSF as biomarker to diagnose Alzheimer’s Disease
Taylor Avei and Dr. John Kauwe, Biology Introduction: The neuropathology of Alzheimer’s Disease (AD) is well-known as a degradation of neural connections in the brain caused by multiple deposits of Amyloid-beta peptide plaques as well as neurofibrillary tangles of tau proteins [1]. Because of this and successful research, both Amyloid-beta 42 and tau protein levels […]
Forward Genetic Screen to Identify Novel Genes Involved in NHEJ DNA Repair
Taylor Brown and Dr. Jonathan Alder, Physiology and Developmental Biology Introduction: DNA contains all the information a cell needs to grow, divide, differentiate, and survive. It also dictates how and when a cell should die. DNA damage (particularly double strand breaks i.e. DSBs) may lead to cell death and/or disease. To circumvent DNA breaks, cells […]
Utilizing the Power of Graphical Processing for DNA Mapping: a Comparison of GNUMAP and BarraCUDA
Lyman, Cole Utilizing the Power of Graphical Processing for DNA Mapping: a Comparison of GNUMAP and BarraCUDA Faculty Mentor: Mark Clement, Department of Computer Science Introduction Recent advances in genome sequencing technologies have resulted in a large increase in the amount of genetic data available. Large Genome Wide Association Studies (GWAS) have the potential to […]
Integration Host Factor Stabilized PCR- amplified DNA for High-Throughput Protein Synthesis Subtitle
William Bradley Faculty Mentor: Bradley Bundy, Dept. of Chemical Engineering Introduction As the search continues for novel proteins with market-incentivized properties, the demand for tools to accelerate the identification of these proteins increases. This has led to investigating methods for screening proteins that yield faster results (high-throughput) with greater titers of protein stable enough for […]
Neofunctionalization of Dual-Targeted Plant Organelle DNA Replication Proteins
Background and Significance Neofunctionalization is the process by which genes gain a new or modified function as a result of gene duplication and modification of one or more of the new genes. This exciting area of research helps explain the diversification of protein functions in cells. The number of documented examples has increased in recent […]
Novel Comet Assay Identifies Preliminary DNA Damage Prior to Cell Apoptosis in Mouse Model of RAGE Over-expression
Steven Knapp and Paul Reynolds, PDBIO Introduction The goal of this project was to characterize the predisposing susceptibility of mice that overexpress receptors for advanced gylcation end products (RAGE) to apoptosis (cell death) and autophagy. Work has already been done to characterize this mouse model as pro-apoptotic; this new project will allow us to identify […]
Characterizing Dna2 in Model Plant Arabidopsis
Connor Woodward and Brent Nielsen, Microbiology and Molecular Biology Introduction Dna2 is a protein that is known to be essential for DNA replication in human and yeast mitochondria. In these organisms it acts as both a helicase and an endonuclease. In the model plant Arabidopsis thaliana an ortholog of Dna2 exists but has never been […]
Bottom-Up Development of Nanoelectronics using DNA Origami Templates
John Jensen and Dr. Adam T. Woolley, Department of Chemistry and Biochemistry Introduction DNA origami is the method of folding a large single stranded DNA (ssDNA) with multiple smaller ssDNA “staple” strands into a predesigned shape, making it an attractive option in the bottom-up construction of nanoelectronic components, such as nanowires. These structures can be […]
Optimizing Metallization of DNA-templated Nanostructures
Andrew Dearden and Adam Woolley, Chemistry & Biochemistry With countless technologies that rely on microprocessors, there is a great need for increasingly smaller microelectronic components. Traditionally, manufacturers have employed a “top-down” approach to build microelectronics – that is, they have attempted to scale functional microcircuitry components down in size, hoping for similar performance in a […]
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