Kyle Kener and Jeffery Tessem, Nutrition, Dietetics, and Food Science Diabetes, a disease characterized by the inability of the body to maintain a normal blood glucose level, continues to affect the lives of many. In both Type I and Type II diabetes, eventual β-cell destruction results in decreased β-cell mass. Regeneration of functional β-cells and […]
Search Results for: cells
Morphology of Human Myoblasts in Cultured Muscle Cells by the Novel Small Molecule SGI
Ryan Matekel and Robert Hyldahl, Exercise Science Introduction Muscle wasting is a symptom of cancer, AIDS, renal failure, heart failure, aging, prolonged bed rest, and has been seen in rodent models for burn, and kidney disease (Han, 2013). Muscle wasting negatively impacts quality of life by decreasing functional independence and increasing morbidity and mortality (Anker, […]
The role of Wnt secretion from Neural Crest Cells in proper craniofacial development
Bradley Haynes and Stark Michael, Physiology and Developmental Biology Introduction Both Wnt signaling and neural crest cells (NCCs) have a well-established role in the development of facial bones and cartilage. Wnt signaling is known to be required for neural crest cell formation; however, Wnt expression originating from the neural crest after their specification by Wnt1 […]
Optimization of Selenium Chemoprevention in Prostate Cancer Cells
Xiuqi Li and Merrill Christensen, Nutrition, Dietetics, and Food Science Introduction Prostate cancer is the most frequently diagnosed cancer and the second-leading cause of cancer death in men in the United States (1). However, most men will die with prostate cancer rather then from it (2). Because prostate cancer exhibits a long latency period, high […]
Inhibition of the Myostatin Signaling Pathway in Cultured Muscle Cells by a Novel Small Molecule
Ryan Matekel and Robert Hyldahl, Exercise Sciences Introduction Muscle wasting is a symptom of cancer, AIDS, renal failure, heart failure, aging, prolonged bed rest, and has been seen in rodent models for burn, and kidney disease (Han, 2013). Muscle wasting negatively impacts quality of life by decreasing functional independence and increasing morbidity and mortality (Anker, […]
Mϋller Cells and Retinal Regeneration
Christopher Burns & Chase Jackson with Dr. Alonzo Cook, Chemical Engineering Introduction Diseases of the retina, such as age-related macular degeneration and diabetic retinopathy, affect millions of people.1 In humans, photoreceptors lost as a result of these diseases are unlikely to be replaced naturally. Thus, these diseases can lead to vision loss. Our team aims […]
The Use of Alpha-1-Antitrypsin (AAT) in the Downregulation of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB) as a Treatment for Acquired Immunodeficiency Syndrome (AIDS)
Aaron McBride and Dr. Gregory F. Burton, Chemistry and Biochemistry Current Human Immunodeficiency Virus (HIV) treatment is greatly hindered due to viral reservoirs throughout the body prolonging and perpetuating infection.i Large stores of HIV exist in the follicular dendritic cell (FDC) microenvironment, located primarily in the lymph nodes and spleen. Free-floating virus has a half-life […]
EBI2 Expression in Different Latency Stages and Primary B Cells
Jillian Markham and Dr. Brian Poole, Microbiology and Molecular Biology Background Epstein-‐Barr Virus (EBV) causes infectious mononucleosis upon primary infection, commonly known as “mono.” Less commonly known is that EBV doesn’t get eradicated from your body after you recover from mono. EBV quietly occupies a small portion of B cells in 90% of human adults […]
Engineering Pathogen Specific High Affinity T-Cell Receptors Linked to Cytokines for Targeting of Antigen Presenting Cells
Bryce Anderson and Dr. Scott Weber, Microbiology & Molecular Biology In February last year I was awarded an ORCA grant which turned out to be the starting of one of my biggest learning experiences here at BYU. My research mentor, Dr. Weber, and I work with the immune system. This semester I have been able […]
IRF7 expression in B cells infected with EBV
Michael Ahlborn and Dr. Brian Poole, MMBIO Dept. Introduction Systemic lupus erythematosus, commonly known simply as lupus, is an incurable autoimmune disorder that can cause inflammation and tissue damage in virtually any part of the body. Many studies have shown a correlation between lupus diagnosis and positive infection with Epstein-Barr Virus (EBV). Scientists currently estimate […]
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