Hyrum Eddington and John M. Chaston, Plant & Wildlife Sciences Introduction: Autism Spectrum Disorder is a neurodevelopmental condition which significantly affects an individual’s social behavior and ability to function in daily living. Although there is a genetic component to the disorder, current research suggests that there are other factors that influence the onset of the […]
Histone Post-Translational Modifications and Nucleosome Positioning: A New Layer in the Histone Code Hypothesis?
Andrew Earl and Dr. Steven Johnson, Microbiology & Molecular Biology Introduction Nucleosomes are the fundamental unit of chromatin organization. They consist of an octamer of histone proteins (two of each H2A, H2B, H3, and H4) wrapped around by 147 base pairs of DNA. Their positioning and occupancy around important genetic elements such as enhancers and […]
CD5 Deficient Mice Exhibit Altered Cognitive Function in Behavioral Studies
Tyler Cox, Work done in lab of Dr. Scott Weber, Microbiology and Molecular Biology Department Introduction The immune system plays a role in protecting and maintaining the central nervous system (CNS). 1Dysfunctions within the immune system can affect the CNS and it is associated with diseases such as Multiple Sclerosis, Alzheimer’s and Parkinson’s disease. Having an […]
Genetic Susceptibility to Co-infections Involving Respiratory Syncytial Virus (RSV): Impact on Immunocompromised Adults
Taylor Brown, Dr. Chantel Sloan, Department of Health Science Respiratory Syncytial Virus (RSV) infects almost all infants before their second birthday and can progress to lower respiratory infections such as bronchiolitis or pneumonia. However, few are aware of the effect this has on adults, particularly those who are immunocompromised through organ or bone marrow transplants, treatments […]
Clinical vs Neuropathological Diagnosis in Alzheimer’s Disease Research
Gage Black and John S. K. Kauwe, Biology Introduction Alzheimer’s Disease (AD) is the most common form of dementia and affects millions of people worldwide. It is the 6th leading cause of death in the United states and the only disease in the top 10 causes of death that does not have a disease altering […]
Morphological variation in Alfaro cultratus across varying stream flow regimes
Kaitlyn Beard Golden and Jerald B. Johnson, Biology Introduction Alfaro cultratus is a freshwater fish native to Costa Rica.1 The common name for Alfaro cultratus is ‘the knife edge livebearer’. It is named after its sharply keeled ventral surface which allows for movement through river currents with speed and agility. Yet this species is a […]
Cell Free Single Stranded DNA Concentration in CSF as biomarker to diagnose Alzheimer’s Disease
Taylor Avei and Dr. John Kauwe, Biology Introduction: The neuropathology of Alzheimer’s Disease (AD) is well-known as a degradation of neural connections in the brain caused by multiple deposits of Amyloid-beta peptide plaques as well as neurofibrillary tangles of tau proteins [1]. Because of this and successful research, both Amyloid-beta 42 and tau protein levels […]
Iron Dysregulation induced by Oxidative Stress is Prevented by Curcumin in C2C12 Skeletal Muscle Cells
Jacob Anderson, Dr. Chad Hancock; Nutrition, Dietetics, and Food Science Introduction Recent studies indicate a correlation between iron dysregulation and insulin sensitivity, suggesting that iron dysregulation may play a role in the development of type 2 diabetes mellitus [1]. However, the connection between iron regulation and insulin sensitivity is not fully understood. Iron is normally tightly regulated, and […]
The Effect of Deep Tissue Heating On Skeletal Muscle PGC1 a Protein Expression During Muscle Atrophy
Kaitlin Abbott, Dr. Allen Parcell, Exercise Sciences Introduction Through this project, we aimed to determine if repeated heat stress is a viable treatment to reduce or slow muscle atrophy in human muscle subjected to disuse. Specifically, I investigated how repeated heat stress affects the expression of PGC1-a, a gene that is an upstream regulator of mitochondrial […]
MEG Final Report
I) Evaluation of academic objectives of the proposal The objectives of this award were met, especially in regard to the mentoring focus of the award. The students have been mentored and trained in an effective manner as outlined in my Mentoring Plan (abbreviated below). This includes mentoring students in research, writing, publishing, presenting at conferences, […]
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