Robert Kitz and Dr. Sandra Burnett, Microbiology & Molecular Biology The Macrophage Fas-Induced Apoptosis (Mafia) mouse is a transgenic mouse model designed by Dr. Sandra Burnett to study the role of macrophages in the absence of macrophages. The Mafia transgene contains the genetic code for the Green Florescent Protein, a suicide gene and a c-fms […]
DNA Barcoding in Chenopodium
Benjamin L. King and Dr. Peter J. Maughan, Plant and Animal Sciences DNA barcoding is one of the most important, novel techniques to be introduced in molecular systematics and genetics research in the last decade. Barcoding has been established as a consistent and reliable indicator of taxonomic relationships in eukaryotes, particularly in animals, where a […]
Identification and Characterization of an Effective Antimicrobial Peptide Defensin and its Effects on Transmission Efficiency
Kody Johnson and Dr. David Erickson, Department of Microbiology and Molecular Biology Among many transmissible infectious diseases falls the Bubonic Plague, a disease that is caused by Yersinia pestis, a bacterium. It is still a concern because there have been human cases as recent as last year in our home state of Utah. While health […]
Twinkle Primase/Helicase Protein in Arabidopsis thaliana
Travis Hunt and Dr. Brent Nielsen, Microbiology and Molecular Biology The overall goal of the project was to study the role of DNA recombination in maintenance of plant mitochondrial DNA (mtDNA). Recombination is the process by which a molecule of DNA is nicked or broken and then the end is joined to a different but […]
Characterization of Osteoarthritic Degeneration in sedc Mutant Mice
David Holt and Dr. Robert Seegmiller, Physiology and Developmental Biology Introduction Spondyloepiphyseal dysplasia congenita (SEDC) is a recessive human genetic disorder characterized by skeletal abnormalities and early onset osteoarthritis (OA).1 Type II and the alpha 3 chain of type XI collagen together are integral in the development of normal articular cartilage (AC) and are both […]
BMP2 Nuclear Variant and Expression of Cancer Genes
Devin Holden and Dr. Laura Bridgewater, Microbiology and Molecular Biology Bone morphogenic protein 2 (BMP2) is a protein that is secreted outside many different types of mammalian cells and has been implicated in the pathogenesis of various forms of cancer. Recently, a variant of this protein that is localized to the nucleus (nBMP2) of the […]
Are Morphology and Performance Predation-related? Swimming Speed and Ontological Shape Comparisons between Populations of a Live-bearing Fish
Elizabeth Hassell and Dr. Mark Belk, Department of Biology I used my ORCA grant for my honors thesis in biology, which has been a great success. The results are not yet complete because the depth of this project goes beyond the one-year time frame of a typical ORCA project; however, our planned schedule is still […]
Correlation Between MC540 Fluorescence and PS Exposure in Apoptotic Cells
Liz Gibbons and Dr. John Bell, Physiology and Developmental Biology The purpose of my project was to further study cell membrane changes during apoptosis, or programmed cell death. This was an extension of the research being done by Dr. Bell and my fellow students on the susceptibility of cells to the enzyme secretory phospholipase A2 […]
The Influence of Elevation on the Life History of Mottled Sculpin
Aaron Fordham and Dr. Dennis Shiozawa, Biology The Mottled Sculpin Cottus bairdii is found in cool to cold streams, creeks and rivers of northern North America (Page and Burr 1991). Sculpin are a benthic fish, living on the bottoms of the streams and rivers that they occupy. They reach 125 to 200 mm in total […]
An In Vitro Examination of the Effect of Cholesterol on Vesicle Exocytosis
Brandon Forbes Neurons communicate to other cells by releasing neurotransmitter through a process called exocytosis. Exocytosis of neurotransmitter containing vesicles to their plasma membranes is via the SNARE protein complex. Studies that have examined the SNARE protein complex, using an in vitro lipid bilayer model, have thus far not examined the effects of cholesterol on […]
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