Glade E. Roper and Dr. Paul B. Savage, Chemistry and Biochemistry Septic shock is a disease that kills over 100,000 hospitalized patients in the United States every year. The mortality rate for those who fall into septic shock is between fifty and eighty percent, and despite advances in medicine this rate has remained constant over […]
Neural Network Topologies
Michael Rimer and Dr. Tony Martinez, Computer Science Neural networks are a statistics-based learning paradigm in which specific acquired data samples are studied to form general rules on how to correctly handle new, unseen data. They have been used to make informed decisions in complex systems, such as predicting stock market trends, controlling robots in […]
DEVELOPMENT OF NEW LIPID A-BINDING AGENTS
Mark Benson and Dr. Paul B. Savage, Chemistry and Biochemistry The aim of this project is to synthesize a non-peptide lipid A-binding agent which is less toxic and simpler than polymyxin B. Such a binding agent could be used to fight sepsis, a toxic condition where the body overreacts to the lipid A portion of […]
Synthesizing a Solution Phase Combinatorial Library to Discover Potent MDR Reversal Agents
John T. Prince and Dr. Merritt B. Andrus, Chemistry and Biochemistry The failure of chemotherapy in treating cancer is largely due to a phenomenon known as Multidrug Resistance (MDR). In MDR, cancer cells that have been exposed to a particular chemotherapeutic drug build up resistance not only to the drug originally administered, but to a […]
The Deformation Path of the Metamorphic Complex, near Santaquin, Utah
Charity M. Phillips and Dr. Ron A. Harris, Geology and Dr. Steve Nelson, Geology The Precambrian rocks on Dry Mountain have been previously mapped by Davis (1983) and Witkind (1985) as Farmington Canyon Complex, found in the Wasatch Mountains near Farmington, Utah. Bryant in 1986 said that these rocks were “probably Farmington Canyon Complex” (FCC). This […]
Removing Points from a Delaunay Tetrahedralization
Nathan Moon and Dr. Bryan S. Morse, Computer Science A set of points in three dimensions can be tetrahedralized, or broken into non-intersecting tetrahedra, in many ways. A Delaunay tetrahedralization of a set of points is a tetrahedralization with the property that the sphere defined by each tetrahedron in the structure does not contain any […]
Comparison of Bootstrap Confidence Interval Methods in a Real Application: The Kappa Statistic in Industry
Kirk O. Monson and Dr. Bruce G. Schaalje, Statistics The kappa statistic is defined as the proportion of agreement between two instruments after chance agreement is removed from consideration (Cohen 1960). It is very useful when assessing the similarities of two instruments or procedures. Industries often use an automated system for testing their products to […]
INVESTIGATION OF THE PYRULARIA THIONIN-EGF MITOTOXIN ON CELL SIGNAL TRANSDUCTION
Andrew B. Adams and Dr. Steven G. Wood, Chemistry and Biochemistry Recently more emphasis has been placed on developing anti-cancer agents with greater specificity and fewer side effects. Immunotoxins and their relatives, mitotoxins, have arisen as possible answers. Mitotoxins are composed of mitogens coupled to plant or bacterial toxins. The mitotoxin under investigation is the […]
Multi-Angle Reflectance Measurements of Uranium at 584 Å
Cynthia E. Mills and Dr. R. Steven Turley, Physics and Astronomy Little is known about the interaction of extreme ultraviolet light (EUV) with materials. This project is a beginning step to filling the information void. My wavelength, 584 Å, is a dominant He I line in the EUV, the 1s 2p to 1s2 transition. The […]
Distribution and Regulation of Na,K-Atpase in Ocular Lens
Adam L. Lunceford and Dr. Steven W. Graves, Chemistry and Biochemistry The Na,K-ATPase is a membrane-bound enzyme found in all cells. This enzyme is composed of an a subunit, which is responsible for the enzyme’s catalytic activity, and a b subunit, which assists in the binding of ions. The three main isoforms of the a […]
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