Emily Parker Updegraff and Dr. Merritt B. Andrus, Chemistry and Biochemistry Chemotherapy is one of the primary methods of combating cancer, and if it fails, the patient may be left with few options for treatment. Multi-drug resistance (MDR) is a clinical condition manifested by the failure of chemotherapy. It is primarily due to the expression […]
Search Results for: synthesis
THE DESIGN AND SYNTHESIS OF A COMPLIANT BICYCLE DERAILER
Matthew Christensen and Dr. Larry L. Howell, Mechanical Engineering Compliant mechanisms are those which gain part or all of their motion from the flexibility of their parts. For example, the motion of a hinge can be alternatively provided by a pin (like a hinge on a door), or by a thin flexible member (like a […]
Synthesis of Lipid A Analogues and the Study of Their Interactions with Antibiotics
Glade E. Roper and Dr. Paul B. Savage, Chemistry and Biochemistry Septic shock is a disease that kills over 100,000 hospitalized patients in the United States every year. The mortality rate for those who fall into septic shock is between fifty and eighty percent, and despite advances in medicine this rate has remained constant over […]
Organic Synthesis of Sulfonated Glycosphingolipids to Study Natural Killer T Cell Stimulation
Dylan Pratt, Brian Anderson, and Dr. Paul B. Savage Abstract The body’s innate immune system is continuously checking our body for molecular structures of antigens on potential pathogens. The CD1d antigen-presenting cell presents glycolipid antigens to Natural Killer T (NKT) cells. NKT cells start a signaling pathway that produces an inflammatory response. 3’’-O-sulfo-Beta-galactosylceramide has been […]
Synthesis of 2-DOS mimic from Diacetone-D-Glucose
Susie Choi and Dr. Young Wan Ham Abstract 2-deoxystreptamine (2-DOS) mimic was to be synthesized in several steps from commercially available diacetone-D-glucose in an effort to prepare novel amino acid residues for antiviral therapeutic development. The method presented in this paper was given up due to unexpected problems occurring at three of the 10 steps. […]
Post-Translational Modification in Cell-Free Protein Synthesis
Anna Katz and Dr. Brad Bundy, Chemical Engineering Introduction The purpose of this project was to examine the phenomenon of eukaryotic myristoylation in a prokaryotic cell-free environment. Basically the idea is that eukaryotic cells such as those within humans have a more robust system for synthesizing protein but it is cheaper, faster, and more easily […]
A Novel Role for AMP-activated Protein Kinase as a Selective Inhibitor of de novo Ceramide Biosynthesis
Kate Erickson and Dr. Benjamin Bikman, Department of Physiology and Developmental Biology The purpose of this project was to determine the cellular mechanisms that mediate AMPK-induced reductions in lipotoxicity. We predicted that AMPK activation inhibits lipotoxic ceramide biosynthesis via targeted reduction in transcription of a critical, rate-limiting enzyme involved in de novo ceramide synthesis. This […]
Cell-free Protein Synthesis Extract Preparation Methods
Troy Holland and Dr. Brad Bundy, Department of Chemical Engineering My ORCA project proposed to test and optimize various low capital cost cell lysis methods, while leaving the internal cell machinery intact and viable for cell-free protein synthesis research. Our cells of interest were a strain of the bacterium E. coli, and their cellular machinery […]
A Combined Computational/Experimental Approach to Stabilize Proteins with Unnatural Amino Acid Modifications
Joshua Wilkerson and Dr. Thomas Knotts, Chemical Engineering Introduction Proteins are versatile biological molecules that catalyze chemical reactions, provide cellular structure, and transport materials throughout the body. Proteins have been adapted for use in a wide variety of industries including food processing, medical diagnostics, and therapeutics. However, proteins must often be modified to enhance their […]
Chemokine Receptor CCBP2-V41A and its Role in Inflammation and Alzheimer’s Disease
Allen Weinert and Scott Weber, Microbiology & Molecular Biology Introduction The leading cause of dementia in elderly patients is Alzheimer’s disease (AD), a degenerating and fatal neurodegenerative condition. AD is a proteopathic disease caused by extensive accumulation of amyloid beta plaques and neurofibrillary tangles. A recent genomewide association study analyzing 59 AD-associated cerebrospinal fluid (CSF) […]
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