Juan Mejia and Juan Arroyo, PhD, Physiology and Developmental Biology Introduction The placenta is an organ composed of highly vascular tissue. It plays an essential role in healthy fetal development as a mediator of gases and nutrients between the mother and fetus. Many complications can occur in this stage of fetal development, such as intrauterine […]
Search Results for: regulation
NF κB as a Mediator in Iron Regulation
Erik D Marchant and Chad Hancock, Nutrition, Dietetics & Food Science Introduction Doxorubicin (DOX) is a commonly used chemotherapy drug. Although it is very effective in treating many different types of cancer, it has also been shown to induce oxidative stress in multiple tissues, partially due to severe iron-dysregulation. The effects of DOX have mostly […]
Iron Dysregulation induced by Oxidative Stress is Prevented by Curcumin in C2C12 Skeletal Muscle Cells
Jacob Anderson, Dr. Chad Hancock; Nutrition, Dietetics, and Food Science Introduction Recent studies indicate a correlation between iron dysregulation and insulin sensitivity, suggesting that iron dysregulation may play a role in the development of type 2 diabetes mellitus [1]. However, the connection between iron regulation and insulin sensitivity is not fully understood. Iron is normally tightly regulated, and […]
Upregulation of humanized HPRT housekeeping gene in malignant tumors hinders use as an endogenous control
Abigail Felsted and Faculty Mentor: Kim O’Neill, Molecular Biology Our lab focuses on developing immunological techniques for diagnosing and treating cancer in a less invasive manner than current methods employ. New unique biomarkers are constantly needed to identify cancer in early stages in order to decrease mortality rates. When researching and publishing such biomarkers, many […]
Dysregulation of Tenascin C and Hyaluronic Acid in Aged Skeletal Muscle
Alex Holland and Faculty Mentor: Alan Parcel, Exercise Science Introduction: Satellite cells are the progenitor stem cells of skeletal muscle (SM) that reside between the sarcolemma and basal lamina. This space is referred to as the satellite cell niche. Following injury, quiescent satellite cells are activated, proliferate then migrate and fuse to the injured region […]
Social Integration and Emotional Regulation
Kimberly Stevens and Dr. Julianne Holt-Lunstad, Psychology Department Introduction Midlife adults face a wide variety of physiological, emotional, and cognitive stressors that place them at risk for impaired physical health and longevity. Social integration—which includes high levels of social engagement as well as maintaining a diverse network of social roles—has been shown to protect against […]
Self-regulation, Inhibition Response, and Perceived Parental Support: an fMRI Investigation of Adolescents with ADHD
Erin Kaseda and Dr. Wendy Birmingham, Psychology Department Introduction It is estimated that between 5-10% of children and adolescents in the United States have been diagnosed with attention-deficit/hyperactivity disorder (ADHD). For adolescents with ADHD, parent-child relationships and peer relationships may experience increased conflict. Interpersonal difficulties among family members put children with ADHD at risk for […]
Emotional Regulation in Marital Therapy
Angela B. Bradford Overview Approximately two years ago we received a MEG grant to support our project Emotional Regulation in Marital Therapy. Clinical research indicates that couples therapy is effective in 30-50% of cases, and although some factors have been identified as predictors of change, there is no research into how these or other factors […]
The Use of Alpha-1-Antitrypsin (AAT) in the Downregulation of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB) as a Treatment for Acquired Immunodeficiency Syndrome (AIDS)
Aaron McBride and Dr. Gregory F. Burton, Chemistry and Biochemistry Current Human Immunodeficiency Virus (HIV) treatment is greatly hindered due to viral reservoirs throughout the body prolonging and perpetuating infection.i Large stores of HIV exist in the follicular dendritic cell (FDC) microenvironment, located primarily in the lymph nodes and spleen. Free-floating virus has a half-life […]
Biofilm Regulation in Yersinia Pseudotuberculosis through Elements Downstream of the BarA/UvrY Two-component System
Jeffrey Schachterle and Dr. David Erickson, Molecular and Microbiology Introduction The bacteria Yersinia pestis is the causative agent of bubonic plague, and its ability to form biofilm in fleas is essential for plague transmission by fleas [1]. Y. pestis recently evolved from Y. pseudotuberculosis (Y. pstb), and the two have nearly identical genomes. Y. pestis […]
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