Spencer Foutz and Dr. John Kauwe, Department of Biology Introduction For the last several years, the e4 allele in the APOE gene region has been a strong determinant of the development of Amyloid Beta plaques in the brain’s cerebral spinal fluid. As these plaques aggregate, the deposits become increasingly deadly to neuronal cells, and can […]
Search Results for: protein
Protein Signaling Effects on Embryonic Limb Formation
Derrick Crawford and Dr. Jeffery Barrow, Developmental Biology Introduction: Congenital limb malformations occur in approximately 1 in 500 live births. These defects are due largely because of genetic and developmental causes. In my experiments, I have researched the source of these defects to understand how cell to cell signaling affects digit and limb formation. I […]
Characterization of the Role of a DNA-Binding Protein on Regulation of DNA Replication in Plant Organelles
Cynthia Perry and Dr. Brent Nielsen, MMBio DNA replication is essential to all life on earth. Not only does replication occur in the nucleus, it also happens in organelles of the cell: the mitochondria and chloroplasts. In higher plants such as Arabidopsis thaliana, the genomes in mitochondria encode proteins which are responsible for DNA replication. […]
Genetic Factors that Influence Tau Protein Levels in CSF and Risk for Alzheimer’s Disease
David Patty and Dr. John SK Kauwe, Biology Alzheimer’s Disease, the most common form of dementia, affects nearly 6 million Americans. Its effects on the individual range from mild impairment of memory to the complete destruction of the victim’s identity and their ability to perform everyday tasks. They become a heavy burden on their family, […]
Discovering Protein Interactions of hR120GCryAB
Kent Jarvis and Dr. Julianne Grose, Department of Micro and Molecular Biology Goal Achievement: The original goal of my project was to find substrates of hR120GCryAB using a yeast two-hybrid model. Over the past few months I was able to achieve this goal. I was able to find over 11 novel substrates that bind with […]
The Unfolded Protein Response Is it the Real Culprit in Osteoarthritis?
Benjamin Fisher and Dr. Laura Bridgewater, Molecular Biology Osteoarthritis (OA) is a disease that affects 26 million of Americans, yet its cause it not understood.1 It is a degenerative disease that affects cartilage at joints, and there are several risk factors that give people a higher probability of developing OA; these risk factors include acute […]
A2 Protein Incorporation into the Qβ Virus-like Particle
Derek Bush and Dr. Brad Bundy, Chemical Engineering Virus-like Particles (VLPs) are noninfectious synthetic copies of the outer protein shell of viruses. They are highly symmetrical nanostructures that self-assemble from approximately 200 copies of a single “coat” protein. This symmetry makes attachment of singular foreign entities to the VLPs difficult, which limits their current uses […]
The Role of the KSHV LANA Protein in Development of Persistent Infections in vivo
Bradford Berges Evaluation of how well the academic objectives of the proposal were met Several of my students have moved on to future positions, as follows: Medical school: Marshall Sheide, Stanton Nielsen, German Cuadra Graduate school: Jamie Gardiner, Steve Hallam (still interviewing) Currently employed: Joel Gardner, Wittnee Estes Jamie Gardiner traveled with me to the […]
Synthesis Of Bioconjugate Dimers Used To Probe The Structure Of PGlycoprotein
Emily Parker and Dr. Merritt B. Andrus, Chemistry and Biochemistry Chemotherapy is one of the primary treatments for cancer today. A patient’s life may depend on its efficacy, so when he or she develops multi-drug resistance (MDR) the results can be devastating. MDR, a clinical condition manifested by the failure of chemotherapy, is primarily due […]
Transmission Electron Microscopy Study of Tobacco Seed Endosperm Transformed With Zein Protein Genes From Zea Mays
Susan Eldredge and Dr. Craig E. Coleman, Botany and Range Science Zein proteins represent the prolamin (alcohol soluble) fraction of maize storage proteins. Zeins constitute approximately 50 percent of the total seed protein in maize, and therefore greatly affect the overall amino acid balance of the maize grain (1). Four different zein subunits (á, â, […]
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