Jeffrey Swallow and Dr. Heidi Vollmer-Snarr, Chemistry Age Related Macular Degeneration (AMD) is the leading cause of vision loss in developed countries. The accumulation of lipofuscin in the eye causes death of the retinal pigment epithelium (RPE) leading to blindness (1,2). The lipofuscin chemical A2E has been shown to have cytotoxic effect in RPE, yet […]
Search Results for: novel
Production of a Novel Anti-Tumor Chemotherapy Agent
Jeffrey Stephens and Dr. Merritt Andrus, Chemistry and Biochemistry Cancer is a condition unlike any other known to man. It is one of the leading causes of death in the United States. In 2000, over 500,000 deaths resulted from various cancers.1 This has led to an extensive search for improved ways to treat cancer, and […]
A Novel Approach to Assessing the Metastatic Potential of Cancer Cells
Nyall Robert London, Jr. and Dr. Kim O’Neill, Microbiology and Molecular Biology Cancer remains a major cause of death around the world today. A major problem with cancer is metastasis or the spread of cancerous cells from the tumor to a secondary location. This occurs when cancer cells break away from a primary tumor, invade […]
Seven Days: A Latin American Historical Novel
David Wiseman and Dr. Douglas J. Weatherford, Spanish and Portuguese Introduction As often is the case in creative writing, the direction of this project deviated slightly from its initial aims. The results, however, surpass in significance the expected outcome of the project’s early development. In order to insure proposed results, this project required extensive research […]
Streamline-Based Novel Dynamic Grid Reservoir Simulation
Bradley C. Bundy and Dr. Larry Lin Baxter / Hugh Bradley Hales, Chemical Engineering Oil is one of the most important commodities we have. It provides energy, transportation, and chemicals to provide a better life for mankind. However, it is a depleting recourse that is getting harder and harder to find and recover. Simulation techniques […]
Novel Preparation and Single Crystal Analysis of Layered Metal-doped Vanadates
Jeffrey Watkins and Dr. Branton J. Campbell, Physics and Astronomy Layered transition-metal-doped bismuth vanadates, commonly known as BIMEVOX oxides, have very attractive oxygen-ion conductivity properties at moderate temperatures and show promise in applications as electrode materials and membranes for oxygen separation. Of great interest is the relationship between the atomic structure of BIMEVOX materials and […]
A Novel Asymmetric Phase-Transfer Catalyzed Approach to the Compounds Ragaglitazar and Kuarsoin A
D. Karl Bedke Asymmetric glycolate alkylation plays a key role in the synthesis of complex biologically active compounds. Such asymmetric transformations have largely to date been accomplished by employing chiral auxiliaries which have shown remarkable success in asymmetric synthesis. However, auxiliaries must also be used in stoichiometric amounts and can become quite expensive. A catalytic […]
Development of a Novel Human Vestibular Schwannoma Xenograft Model in SCID Mice
John Welling and Dr. Kim O’Neill, Microbiology and Molecular Biology Introduction Vestibular Schwannoma (VS) is a benign, slow growing tumor that arises from the myelin sheath of the vestibular nerve (cranial nerve VIII). The myelin sheath is composed of flat, layered cells known as Schwann cells, which serve to insulate nerve fibers. It is increased […]
Intracellular Localization of a Novel BMP-2 Variant Protein Involved in Col11a2 Regulation
Carolina M. Montaño and Dr. Laura C. Bridgewater, Microbiology and Molecular Biology Cartilage is a type of connective tissue that is found in many parts of the skeleton and covers the joint surfaces of bones. It consists of an abundant extracellular matrix (ECM) that is produced and maintained by chondrocytes. This ECM includes type II, […]
Description of a Novel Mutant Entemopathogenic Bacterium Photorhabdus luminescence
George Bailey and Dr. Byron J. Adams, Microbiology and Molecular Biology The bacterium Photorhabdus luminescence and the nematode Heterorhabditis bacteriophora share an intimate symbiotic relationship. Together, the pair preys on insect larva in the soil. Infective juvenile (IJ) nematodes seek out insect hosts by following chemical signals, such as CO2, given off by potential hosts. […]
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