Charles Teames and Scott Weber, Microbiology & Molecular Biology Introduction Regulatory T cells (Tregs) inhibit the immune response and play a key role in preventing autoimmunity. Unfortunately, Tregs also often prevent an effective immunological response against cancer. CD5 is a T cell surface protein known to regulate the threshold for T cell activation. CD5 is […]
Search Results for: molecular
TK1 as a Biomarker of Chemosensitivity and Metastatic Potential in Breast Tumors
Eric Olsen and Kim O’Neill, Microbiology and Molecular Biology Introduction Breast cancer is the most common form of cancer in women, accounting for 23% of total cancer cases and 14% of cancer deaths. Breast carcinoma is not a simple disease. It is comprised of many different biological forms with distinct phenotypes and prognoses. Hormone receptor […]
Could TK1 Suppress the Immune System and Promote Tumor Development?
Joshua Keller, Roman Kovtun, Kim O’Neill, Microbiology & Molecular Biology Cancer is a widespread disease that affects millions of people worldwide and in many cases is difficult to treat. In order to find new and better treatment, it is important to understand how this disease progresses. Thymidine Kinase 1 (TK1) is a recognized biomarker that is […]
Quantifying predictive value of biological data types in machine learning models of cancer outcome
Samantha Jensen, Stephen Piccolo, Biology Precision medicine is a growing movement toward utilizing molecular diagnostics to guide medical decisions. It is particularly useful when applied to cancer treatment, as knowing details about cancer stage, genetic pathology, and tumor type can inform life-saving decisions. Increasingly, physicians may use genetic, proteomic, epigenetic, and expression data to determine treatment […]
Revision of the genus Gilia of Utah
Zachariah Jaramillo, Dr. Leigh Johnson, Biology Department Introduction The genus Gilia has historically been difficult to work with because identification of the genus via a dichotomous key relies heavily on the absence of characteristics instead of the presence of unique characteristics (Johnson et al., 2004). This has caused Gilia to become a polyphyletic group that […]
Characterization of Mutant Chemokine (C-C) motif Receptor-Like 2 (CCRL2) and its Role in Inflammation and Alzheimer’s Disease
Meganne Ferrel and Dr. John S. K. Kauwe, Biology Introduction Alzheimer’s Disease (AD) is identified as a proteopathic disease that results from an extensive accumulation of amyloid plaques and neurofibrillary tangles in the brain. Several researchers have discovered that cerebrospinal fluid (CSF) contains biomarkers for AD such as Amyloid-beta and tau. Neuritic plaques in AD […]
Cancerous Male and Female Gene Expression
Clarissa Farmer and E. Shannon Tass, Statistics Genetic diagnosing is becoming more popular, as well as more and more accurate. However, many genetic diseases have complex genetic effects and are still not fully understood. Transthyretin Amyloidosis (ATTR; also known as familial or hereditary amyloidosis) is a terminal genetic disease. It is caused by unstable transthyretin […]
Histone Post-Translational Modifications and Nucleosome Positioning: A New Layer in the Histone Code Hypothesis?
Andrew Earl and Dr. Steven Johnson, Microbiology & Molecular Biology Introduction Nucleosomes are the fundamental unit of chromatin organization. They consist of an octamer of histone proteins (two of each H2A, H2B, H3, and H4) wrapped around by 147 base pairs of DNA. Their positioning and occupancy around important genetic elements such as enhancers and […]
Modeling Main Group Metal Alkane Functionalization Reactions in Highly Acidic Carboxylic and Sulfuric Acid Solvents
Lily H. Carlson, Prof. Daniel H. Ess, Chemistry Department Our group is interested in identifying the unknown mechanisms of main-group C-H functionalization reactions. In the long term, our goal is to use computational chemistry tools to develop general principles on mechanisms, intermediates, reactivity, and selectivity for hydrocarbon C-H functionalization reactions by p-block main-group compounds as well […]
Cyclic Peptide Catalyst design
Millicent Campbell, David Michaelis, Department of Chemistry and Biochemistry Enzymes found in nature are more efficient catalysts than those used in organic chemistry labs. However, natural enzymes are not ideal for organic synthesis because they only make one product and only work in specific conditions. The Michaelis lab designed a catalyst capable of mimicking enzyme-like reactivity […]
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