Tacie Hall and Dr. Julianne Grose, Department of Microbiology and Molecular Biology When PAS kinase is knocked out in mice placed on high-fat diets, these mice show such symptoms as decreased weight gain, hypermetabolic phenotype, decreased liver triglyceride accumulation, and retained insulin sensitivity when compared with their wild type littermates.1 These symptoms are highly associated […]
Search Results for: molecular
Determining the Role of Kaposi’s Sarcoma-associated Herpesvirus LANA Protein in the Development of Persistent Infection
Jamie Gardiner and Dr. Brad Berges, Department of Microbiology and Molecular Biology Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is a human cancer virus that causes Kaposis’ sarcoma, the most common cancer found in AIDS patients. Our lab is working to develop humanized mice as a novel animal model to study KSHV infection and related diseases, since there […]
The Neuroprotective Effects of Exercise on LTD in the Hippocampus
Adam Field and Dr. Jeff Edwards, Department of Physiology and Developmental Biology In April of 2012, IACUC committee approved the methods which we had set forth for the carrying out of the experiment. At this point we began gathering the tools and materials needed for the performing of the experiment. Mice were obtained, and the […]
Premature Osteoarthritis in the Temporomandibular Joint of Heterozygous Disporportionate Micromelia Mice
Jason Farrell and Dr. Robert Seegmiller, Department of Physiology and Developmental Biology Purpose of the Study The purpose of this study, as also summarized in the proposal for this research grant, was to analyze the temporomandibular joints (TMJs) of mice with a specific collagen defect, Disproportionate Micromelia. Examining these joints was done to provide an […]
Diversification Rates, Phylogenetic Relationships, and Character Evolution within an Ancient Group of Decapod Crustaceans (Anomura: Decapoda)
Maren Ettinger and Dr. Keith Crandall, Department of Biology The purpose of phylogenetics is to understand the evolution of a group of organisms and to resolve the relationships within groups. Once phylogenies are created, they can be used for a number of different analyses. My project focused on using a phylogeny of the infraorder Anomura […]
CASTing for a Putative DNA Binding Sequence for nBmp2
Brian Earley and Dr. Laura Bridgewater, Department of Microbiology and Molecular Biology Bmp2 is a secretory mammalian protein that plays important roles in bone development and adult pathology. Recently, a nuclear variant (nBmp2) was discovered with an unknown function for this typically secretory protein in the nucleus (Felin et al., 2010). The purpose of this […]
Novel and Integrative Approaches to Articulating the Pancrustacean Tree of Life
Alan Colver and Dr. Keith Crandall, Department of Biology The taxonomic group Pancrustacea encompasses more than half of the world species. The two main groups within Pancrustacea are the crustaceans and hexapods (insects). Understanding these two groups will aid in preservation, population control, and economic pursuits involving these groups. In our evolutionary analysis, six different […]
Ex Vivo Infection and Re‐isolation of Human Herpesvirus 6
Stephanie Carlson and Dr. Bradford Berges, Department of Microbiology and Molecular Biology Science rarely cooperates as anticipated, but that can often lead to unexpected insight and solution. I ran into that this semester with a certain aspect of our project. We are continuing to collect data for the American Society for Virology in late July […]
Genomic and Proteomic Analysis of an Erwinia amylovora Phage
Alicia Brighton and Dr. Julianne Grose, Department of Microbiology and Molecular Biology Introduction Fireblight is a disease, caused by the bacteria Erwinia amylovora, that can infect some fruit trees, including apple and pear trees. When an infection occurs, the effects can be devastating—any infected part of the tree must be removed and destroyed, sometimes resulting […]
Effects of Nicotine on Plasticity in Glutamate Neurotransmission to Midbrain GABA Neurons
Peter Nielson and Dr. Scott Steffensen, Department of Psychology Purpose In order to further the knowledge of physiological contributions to addiction, this project’s purpose was to elucidate the neuronal processes involved in nicotine (NIC) addiction. We studied its effects on critical neuronal substrates in the ventral tegmental area (VTA), an area of the midbrain implicated […]
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