Dr. Jerry Johnson, Department of Biology This mentoring environment grant was awarded in 2010 and was intended to spent over a two year period. The purpose of the project was to provide up to six students with an opportunity to participate in three different research aspects of a single research problem related to understanding speciation. […]
Search Results for: molecular
Supramolecular Chemistry for Students
Drs. Roger Harrison, John Lamb, David Dearden, Department of Chemistry & Biochemistry Evaluation of how well the academic objectives of the proposal were met Students working in the mentoring environment synthesized compounds and worked with separation and mass analyzer instruments. They learned how to make new compounds by organic synthesis and characterize their compounds by […]
A Race Against Time: Deciphering Evolution and Describing New Species of Threatened Tropical Stick Insects (Phasmatodea)
Michael F. Whiting, Biology Funding was received in 2016 to support mentored research into the phylogeny and evolution of stick insects. Specific goals include providing students with scientific design experience, field-based research experience, collections-based experience, molecular lab experience, bioinformatics experience, and experience in presentation at national meetings and publication in peer reviewed journals. One particular […]
T Cell Immunotherapy of Infection Disease and Cancer
Scott Weber, Microbiology and Molecular Biology 1) Project Summary This project was focused on improving the immune response to infectious disease and cancer. We have engineered T cell receptors with 1000-fold increase in affinity and will characterize their value as diagnostics and therapeutics. In addition, we examined changes in T cell function due to the […]
Development of Real-Time Polymerase Chain Reaction (q-PCR) Assays for the Detection and Identification of Drug-resistance Genes in Carbapenem-resistant Enterobacteriaceae (CRE)
Richard A. Robison, Ph.D., Microbiology and Molecular Biology I. The Specific aims for the project were as follows: Develop q-PCR assays for the various carbapenem-resistance genes, such as KPC, IMP, VIM, and NDM-1, and then multiplex them into single assays that can be used to quickly characterize an isolate. II. Accomplishments to date related to […]
Combating Obesity Through Gut Microbiome Targeted Bacteriophage Therapy
Gongze Zhao, Dr. Laura Bridgewater, Micro & Molecular Biology Introduction The human gut consists of approximately 1.5 kg of bacteria, and 50% of the biomass in our fecal matter is bacterial cells (Nicholson, 2005). Diet is a major factor in shaping the composition of the gut microbiota, (Zhang, 2010) which in turn influences the body by […]
The Role of Nr4a1 in β-cell Growth and Onset of Type 2 Diabetes
Adam Wynn, Jeffery Tessem, Ph.D. Nutrition, Dietetics, and Food Science Progression to type 2 diabetes (T2D) includes a loss of functional pancreatic beta cells (β-cells), which are responsible for secreting insulin and maintaining healthy blood sugar levels. Nr4a1 is a gene that has been shown to be involved in fuel utilization in the liver, muscles, and […]
A Combined Computational/Experimental Approach to Stabilize Proteins with Unnatural Amino Acid Modifications
Joshua Wilkerson and Dr. Thomas Knotts, Chemical Engineering Introduction Proteins are versatile biological molecules that catalyze chemical reactions, provide cellular structure, and transport materials throughout the body. Proteins have been adapted for use in a wide variety of industries including food processing, medical diagnostics, and therapeutics. However, proteins must often be modified to enhance their […]
Chemokine Receptor CCBP2-V41A and its Role in Inflammation and Alzheimer’s Disease
Allen Weinert and Scott Weber, Microbiology & Molecular Biology Introduction The leading cause of dementia in elderly patients is Alzheimer’s disease (AD), a degenerating and fatal neurodegenerative condition. AD is a proteopathic disease caused by extensive accumulation of amyloid beta plaques and neurofibrillary tangles. A recent genomewide association study analyzing 59 AD-associated cerebrospinal fluid (CSF) […]
Guided Evolution to Expand the Host Range in Phages
Jamison Walker and Sandra Hope, Microbiology & Molecular Biology My project proposal included the use of Darwin’s theory of evolution by natural selection to determine if genetic mutations will arise in Bacteriophages that would allow them to infect related strains in a species of bacteria. Bacteriophages naturally have a target host range that they can […]
- « Previous Page
- 1
- …
- 4
- 5
- 6
- 7
- 8
- …
- 63
- Next Page »