Steven Butler and Faculty Mentor: Daniel Ess, Department of Chemistry and Biochemistry There is now access to vast amounts of inexpensive natural gas, due in part to shale gas discoveries. Abundant natural gas provides significant motivation to develop methods for methane partial oxidation. One major target for methane oxidation is methanol. Natural gas is principally […]
Search Results for: mechanism
Neural mechanisms: Nicotine and Alcohol Co-dependence
Jordan Spencer and Dr. Scott C. Steffensen PhD, Department of Psychology and Center for Neuroscience Introduction: Alcohol abuse is prevalent in today’s society, causing an economic burden to the US of several hundred billions of dollars annually in direct costs alone. Several reports have estimated that 80% of those with a dependence on alcohol are […]
Neural Mechanisms of Inhibitory Control: Predictors of Eating Behavior in Obesity
Kaylie Carbine ande Michael Larson, Department of Psychology and Neuroscience Introduction Obesity is a prominent public health concern associated with increased risk of high blood pressure, chronic diseases, and mortality (National Institutes of Health, 2011). Understanding the neural underpinnings of obesity may prove beneficial for effective weight control interventions. Specifically, decreased ability to inhibit responses […]
Mechanism of Assembly of the Bardet-Biedel Syndrome (BBS) Complex
Barry M Willardson, Chemistry and Biochemistry Students Involved Devon Blake. Devon was the most productive student I have had in my 18 years at BYU. The MEG award helped support his work from January 2013 through May 2014. During this time, Devon co-authored two papers on the effects of cell-type specific deletion of phosducinlike protein […]
Extent and Mechanism of Translational Readthrough in Humans
Michael Porter and Dr. John Prince, Department of Chemistry and Biochemistry Introduction Proteins are an integral part of the cell. They are responsible for metabolism, DNA replication, transportation, and responding to changes in environment. Because of their importance to the cell, proteins are often drug targets due to the important roles they play in carrying […]
Autophagy-Mediated Mechanisms of Chemoresistance in Cancer
David Broadbent, Dr. Joshua Andersen, Department of Chemistry and Biochemistry The resistance of tumor cells to chemotherapy is a critical problem in the clinic and is a common cause of mortality in cancer. Emerging data suggests that resistance to chemotherapy is caused by a tumor-expressed protein called 14-3-3ζ, yet the mechanism to explain 14-3-3ζ-mediated chemoresistance […]
A New Dominance Mechanism for Evolutionary Optimization
Braden Hancock and Dr. Christopher A. Mattson, Mechanical Engineering Department Introduction Nearly one year ago, we proposed the development of a mechanism for evolutionary optimization that would provide the widely recognized benefits of ε-dominance methods while simultaneously supporting Pareto knee exploitation. Thanks to the ORCA grant that we received to pursue this research opportunity, we […]
Structure of the PhLP1-Gβ-CCT Complex Reveals a Molecular Mechanism for Gprotein β Subunit Folding and βγ Dimer Assembly
Devon Blake and Dr. Barry Willardson, Chemistry and Biochemistry Introduction and Project Importance Cells detect and respond to a myriad of extracellular signals via seven-transmembrane G protein-coupled receptors and their associated G protein signaling pathways. The pathway is initiated by the binding of a signaling molecule, such as a hormone or neurotransmitter, to its binding […]
Ceramides, Mitochondrial Fission, and Reactive Oxygen Species, A Novel Mechanism of Obesity-induced Insulin Resistance
Braden Tucker and Dr. Benjamin Bikman, Physiology and Developmental Biology Introduction: With the unabated rise in obesity in the United States and globally (1), increasing efforts are being devoted to understand and prevent both the onset and the consequences of excess fat gain. As evidenced by health trends, efforts to curtail weight gain have proven […]
Effects of Locus of Control on the Neural Mechanism of Error Processing
Kaylie Carbine and Dr. Michael Larson, Department of Psychology and Neuroscience Introduction Performance monitoring is the ability to assess behavior and make necessary adjustments (Ullsperger & von Cramon, 2001). Performance monitoring can be examined through event-related potentials (ERPs), which are indicators of the brain’s electrical activity in response to a specific stimulus (Luck, 2005). One […]
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