Caitlin Nichols and Dr. Laura Bridgewater, Department of Microbiology and Molecular Biology Purpose The purpose of this study was to determine whether the Dmm, cho, and sedc mutations in mice collagen genes activate unfolded protein response (UPR) pathways in developing cartilage tissues. The inflammation or cell death triggered by the UPR may contribute to the […]
Search Results for: characterization
Determining Functions of a Nuclear Variant of the Growth Factor Bmp2
Evan D. Davis and Dr. Laura C. Bridgewater, Microbiology & Molecular Biology Bone morphogenetic protein 2 (Bmp2) is a secreted growth factor that modulates many essential physiological and developmental processes by means of extracellular signaling (1). Several of these processes include neuronal differentiation, cardiac development, and skeletal muscle development (1-5). Dr. Laura Bridgewater at Brigham […]
Synthesizing a Solution Phase Combinatorial Library to Discover Potent MDR Reversal Agents
John T. Prince and Dr. Merritt B. Andrus, Chemistry and Biochemistry The failure of chemotherapy in treating cancer is largely due to a phenomenon known as Multidrug Resistance (MDR). In MDR, cancer cells that have been exposed to a particular chemotherapeutic drug build up resistance not only to the drug originally administered, but to a […]
A Weak Structural Approach to Decentralized Control
David Ward and Dr. Sean Warnick, Computer Science The research discussed here explores the interplay between dynamical structure functions, the communication structure of a controller and the zero pattern of a controller. Precisely understanding this interplay is a necessary result to utilize dynamical structure functions to help broaden the known tractable class of decentralized control […]
Ruth: The Power of Personality and the Comedic Promise of Deliverance
Elisabeth German and Dr. Steve Walker, English Main Text For my project, I wrote a chapter for Dr. Walker’s book on humor and the Bible entitled, Man Thinks, God Laughs. The purpose of the book is to teach readers to see the text of the Bible through a helpful (albeit atypical) lens: that of humor. […]
A Study of Biological Photonic Crystals in the Internal Opal Scale Structures of Iridescent Beetle Species in the Cerambycidae Family
Lauren Richey and Dr. John Gardner, College of Life Sciences Main Text A photonic crystal is a periodic structure that confines, manipulates, and guides photons. Such structures affect the propagation of electromagnetic waves by defining allowed and forbidden frequency bands known as photonic band gaps. Therefore, a photonic crystal can be thought of as the […]
The Role of Nectin In Zyxin Localization
Jace Bullard and Dr. Marc Hansen, Department of Physiology & Developmental Biology Abstract A major difficulty of treating cancer rises from its ability to metastasize. During metastasis, strong adhesions between cells break, allowing individual cells to separate and migrate to different locations in the body. Strong cell-cell junctions are formed by protein interactions between actin […]
Corrosion Measurement of Reinforcing Steel in Concrete Using Electrochemical Impedance Spectroscopy
Eric Sumsion and Dr. Spencer Guthrie, Department of Civil and Environmental Engineering Introduction Corrosion affects reinforced concrete structures throughout the world. Corrosion, induced by concrete carbonation and penetration of chloride ions from deicing salts and/or seawater, reduces the load-bearing area of reinforcing steel, weakens the bond between steel and concrete, and cracks the concrete surrounding […]
Developing the Confocal and Fluorescence Microscopy Techniques to Visualize the eLiposomes Inside of Cells to Treat Cancer
Tara Pandey and Dr. William Pitt, Department of Chemical Engineering Cancer is among the leading causes of death in the world. The goal for this project was to visualize a liposome containing perfluorocarbon emulsion an eLiposome, inside of tumor cells using confocal and fluorescence microscopes. A successful study of this project would help to understand […]
Spinning Objects in a Shallow Bath: Eggs in Milk
Kenneth Langley and Dr. Tadd Truscott, Department of Mechanical Engineering Introduction If an egg spinning on a counter-top passes through a shallow pool of milk, a thin film of milk will be drawn up the sides of the egg and sprayed on the counter-top. This phenomenon is not limited to eggs or milk. In fact, […]