Trever Bradley Burgon and Dr. Gregory F Burton, Microbiology Human Immunodeficiency Virus (HIV), the retrovirus that causes Acquired Immunodeficiency Syndrome (AIDS), has infected over 60 million people and become what the Joint United Nations Program on HIV/AIDS calls: “the most devastating disease mankind has ever faced” (8). Current treatment, known as HAART (highly active antiretroviral […]
Search Results for: cells
The Inhibitory Affects of Phytochemicals against a Carcinogen by the Modulation of Xenobiotic Enzymes in HepG2 Cells
Jon Ahlstrom and Dr. Kim O’Neill, Microbiology Cancer is the cause of death of 1 in 3 citizens in the United States. A diet rich in fruits and vegetables can reduce cancer deaths by 33%. Cancer prevention from dietary plants may in part be derived from individual phytochemicals inherent to the plant. The identification of […]
Ultrasound-activated Delivery of Doxorubicin from Polymeric Micelles to Breast Cancer Cells
Philip D. Blood and Dr. William G. Pitt, Chemical Engineering A major limitation to the effectiveness of cancer chemotherapy is the toxic side effects it has on normal tissues. Thus, it would be highly advantageous to develop a form of treatment that allows higher doses of drugs to be delivered to tumors without increasing the […]
HIV in The Immune System: The Role of Specialized Follicular Dendritic Cells in Promoting Viral Disease
Jacob D. Estes and Dr. Gregory F. Burton, Microbiology Human Immunodeficiency Virus (HIV) has become a world wild epidemic affecting millions of people across the globe. Even in the face of potent antiviral drugs which are only available in first world countries, HIV continues to evade intervention strategies and eventually destroy the body’s immune system. […]
The Potential for Grape Seed Extract as an Antioxidant in Human Cells
Mark J. Eliason and Dr. Kim O’Neill, Microbiology The single-cell gel electrophoresis assay or “Comet Assay” is a novel test which can be used to empirically ascertain the degree of damage sustained by the DNA of individual cells when exposed to cytotoxic chemicals. In this experiment a known cell line was grown in varying concentrations […]
Molecular Pathology of Age-related Macular Degeneration: Lipofuscin-generated Apoptosis of Human Retinal Pigment Epithelial (RPE) Cells
Aaron Secrest and Dr. Craig Thulin, Chemistry and Biochemistry Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment in the elderly and is currently untreatable. In the central region of the posterior retina (the macula), AMD is caused by damage to and subsequent death of retinal pigment epithelial (RPE) cells and, consequently, […]
Investigating HIV Trapping By Follicular Dendritic Cells
Benjamin E. Farnsworth and Dr. Gregory F. Burton, Chemistry and Biochemistry The human immunodeficiency virus (HIV) targets immune cells, specifically CD4 T Cells. Infection of these cells by the virus eventually renders the immune system incapable of proper function, and ultimately results in the death of the patient. Highly active anti-retroviral drug therapies (HAART) have […]
Follicular Dendritic Cells as Reservoirs of Diverse Human Immunodeficiency Virus: A Phylogenetic Analysis
Trever Bradley Burgon and Dr. Gregory F. Burton, Chemistry and Biochemistry Introduction Human Immunodeficiency Virus (HIV), the retrovirus that causes Acquired Immunodeficiency Syndrome (AIDS), currently infects over 42 million people; more than three million of them are children under the age of 15. The Joint United Nations Program on HIV/AIDS calls the current AIDS epidemic: […]
An Exploration of the Genotoxic Effects of Ellagic Acid on Human HepG2 Cells and Its Potential Impact on Cancer Prevention
Amanda Stevens and Dr. Kim O’Neill, Microbiology and Molecular Biology Over the past few years, cancer prevention has become a more important focus for research in the fight against cancer. Recent studies suggest that perhaps as much as 70-80 % of all cancers could be prevented by diet alone. Ellagic acid is a compound found […]
Chondrogenic Differentiation of Adult Hepatic Stem Cells: Investigating Candidates for Osteoarthritis Treatment
Jaron Coombs and David Sonntag with Dr. Laura Bridgewater, Molecular and Microbiology Osteoarthritis is a painful disease associated with the breakdown of articular cartilage, the protective protein coating of the major joints of the body. Over 20 million Americans are affected by this pervasive disease which is associated with the overuse of joints and aging. […]
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