Amy Twitchell and Faculty Mentor: Robert Hyldahl, Exercise Science Introduction: Exercise has been known to improve mitochondrial function and increase its content in muscle. However, those who suffer from certain diseases such as Chronic Obstructive Pulmonary Disease (COPD) and Type II Diabetes often experience concomitant exercise intolerance. In vitro research suggests that the application of […]
The Effect of Repeated Heat Stress on Mitochondrial Protein Content in Human Skeletal Muscle
Amy Twitchell and Faculty Mentor: Robert Hyldahl, Exercise Science Introduction: Exercise has been known to improve mitochondrial function and increase its content in muscle. However, those who suffer from certain diseases such as Chronic Obstructive Pulmonary Disease (COPD) and Type II Diabetes often experience concomitant exercise intolerance. In vitro research suggests that the application of […]
TK1; Journey from the Cytoplasm to the Cell Membrane
Weston Burrup and Kim O’Neill, Microbiology and Molecular Biology Thymidine Kinase 1 is an enzyme involved in the synthesis of thymidine triphosphate, an essential DNA building block needed for cell replication. Previous research has shown an upregulated level of TK1 in the serum levels of cancer patients as well as on the cancer cell surface. […]
Maternal-Fetal Interactions and the Induction of Preeclampsia by Growth arrest-specific 6 (Gas6)/AXL Signaling
Todd Dunaway and Paul Reynolds, Physiology and Developmental Biology Introduction: Preeclampsia (PE) is a complicated obstetric complication characterized by increased blood pressure and decreased trophoblast invasion. PE is one of the leading causes of maternal and fetal morbidity and mortality in developed countries. The growth arrest-specific 6 (Gas6) protein is known to induce different responses […]
Effect of Restricted Ankle Mobility on Muscle Reaction Time and Ankle Joint Kinematics to a Simulated Ankle Sprain during Walking in Chronic Ankle Instability Patients
Brandon Winward and Faculty Mentor: Ty Hopkins, Exercise Science Department Introduction Inversion ankle sprains are common and are caused by sudden inversion stresses during weight-bearing movement which causes the foot to roll under and inward.1 Ankle sprains result in tearing or stretching of ligaments and muscles, which reduces ankle stability.2 After a single ankle sprain, […]
Elucidating the Role of the Transcriptional Co-activator camta1 in Cardiac Development
Nate Batey, Zach Frederich, Morgan Fronk, Nate Jenkins and Jonathon Hill, Physiology and Developmental Biology Introduction Congenital Heart Disease (CHD) is the most common type of birth defect in the United States, causing more first-year infant deaths than any other birth defect (1). While the causes of CHD are varied, genetic defects are known to […]
Identifying Novel Regulators of Cellular Respiration
Sam Nicholes and Faculty Mentor: Julianne Grose, Microbiology and Molecular Biology The impetus behind my project was to contribute in a small but meaningful way to the growing body of research for cures and treatments for cancer. Cancer is fundamentally unwanted cell growth and proliferation. Metabolic processes that take place on the cellular level are […]
Dysregulation of Tenascin C and Hyaluronic Acid in Aged Skeletal Muscle
Alex Holland and Faculty Mentor: Alan Parcel, Exercise Science Introduction: Satellite cells are the progenitor stem cells of skeletal muscle (SM) that reside between the sarcolemma and basal lamina. This space is referred to as the satellite cell niche. Following injury, quiescent satellite cells are activated, proliferate then migrate and fuse to the injured region […]
“Seeing” Beyond the Knees: Inflammation in the Eye as a Result of Mechanical Stress
Michael Goodman and Faculty Mentor: David Kooyman, Physiology and Developmental biology A correlation between Osteoarthritis (OA), affecting over 27 million people in the US [1], and metabolic syndrome (MS), affecting over 340 million people worldwide [2], becomes strikingly important as the search for an effective treatment for OA continues. Increasing evidence has shown that OA […]
Incorporating Ground Juniper Wood into Sagebrush Seed Agglomerates as a Fungicide Alternative
Benjamin Hoose and Faculty Mentor: Matthew Madsen, Plant and Wildlife Sciences Sagebrush seed agglomerates (referred to as ‘agglomerates’ in the remainder of the report) are small balls of seed, clay, and compost that allow us to treat sagebrush seeds with germination enhancers. The goal of my project was to determine whether we could use the […]
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