Joseph Linzey and Dr. Scott Steffensen, Neuroscience Research concerning whether or not D2 receptors can be used as an accurate biomarker for drug addiction is still currently underway. Unfortunately, this semester I was unable to engage in research nearly as much as I had planned. I spent a lot of time this semester interviewing at […]
Search Results for: receptor
Localizing Endocannabinoid Receptors GPR55 and GPR119 to Subtypes of Neurons in the Hippocampus
Ryan Williamson and Dr. Jeff Edwards, Department of Physiology and Developmental Biology The hippocampus is the part of the brain that mediates learning and memory by altering the function of synapses within its circuitry via intracellular signaling molecules. The ability of synapses to change is called synaptic plasticity. Hippocampal synaptic plasticity can be mediated by […]
Over-expression of AGE Receptors in the Adult Mouse Lung A New Model for the Study of COPD
Megan Stogsdill and Dr. Paul Reynolds, Physiology and Developmental Biology Receptors for advanced glycation end products (RAGE) are receptors that can bind a variety of ligands and are members of the immunoglobin family of cell surface receptors. RAGE is found in many tissue types during inflammatory lesions but is found most abundantly in the lung, […]
Up-regulation of Receptors for Advanced Glycation End-Products (RAGE) in the Lung Results in Significant Tissue Loss and Neonatal Lethality
Jeff Stogsdill and Dr. Paul Reynolds, Department of Physiology and Developmental Biology The receptor for advanced glycation end-products (RAGE) is becoming an increasingly popular molecule of study after having been initially characterized in relation to a number of diseases such as diabetes, Alzheimer’s and atherosclerosis among others. It has recently been noted that RAGE is […]
Targeting IgA Antibody Responses to Mucosal Tissues Through Chemokine Receptor Manipulation
Eric Wilson, Department of Microbiology and Molecular Biology Proper functioning of cells of the immune system is highly dependent on their efficient accumulation to tissues where infection may occur. These cells migrate throughout the body to sites of possible infection via arteries and blood vessels, much like commuters travel to their places of employment via […]
A Novel Human Angiotensin Ii Type 1 Receptor Isoform Elicits an Exaggerated Angiotensin Ii-induced Response
Terry S. Elton and Dr. James W. Ogilvie Jr., Biochemistry and Chemistry Hypertension (i.e., high blood pressure) is a significant health problem affecting more than 15% of the population contributing to the increased incidence of heart failure, kidney failure and stroke. The renin-angiotensin system (RAS) plays a pivotal role in salt and water homeostasis and […]
A Search for an Internal Ribosomal Entry Site in the Human Angiotensin 2, Type 1 Receptor
Joseph A. Garcia and Dr. Terry S. Elton, Chemistry and Biochemistry The study of human genetics has recently exploded into numerous fields and, as a result, our knowledge of genetics and gene related illnesses is growing exponentially. Human DNA undergoes three main levels of control. The first is replication where the genome is reproduced in […]
Down-regulation of HIV-1 Receptors and Inhibition of HIV-1 Entry by Prostratin Treatment
Richard Turley and Drs. Richard A. Robison and Gregory F. Burton, Microbiology Due to recent findings that HIV replication can persist even with highly active anti-retroviral therapy (HAART), it has become increasingly necessary to develop new therapies that can be used as adjuncts with HAART, to combat HIV infection. One possible alternative strategy is to […]
Fc Receptors in HIV Trapping and Retention on Follicular Dendritic Cells
Daniel Willis and Dr. Gregory Burton, Microbiology The development of HighlyActive Antiretroviral Therapy (HAART) against the HIV virus created a temporary excitement regarding a possible cure for HIV. This optimism resulted due to the fact that HAART blocked active HIV replication and reduced the level of HIV in the bloodstream to below standard limits of […]
DEVELOPMENT OF A NEW SUGAR RECEPTOR
William D. Thomas and Dr. Paul B. Savage, Chemistry & Biochemistry Oligosaccharides are enormously rich in structural information. They are often branched and can be bonded together by a variety of different linkages, unlike polypeptides which contain identical peptide bonds.1 For this reason, polysaccharides play a crucial role in cell recognition.2 Although carbohydrate recognition is […]
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