Steven Knapp and Paul Reynolds, PDBIO Introduction The goal of this project was to characterize the predisposing susceptibility of mice that overexpress receptors for advanced gylcation end products (RAGE) to apoptosis (cell death) and autophagy. Work has already been done to characterize this mouse model as pro-apoptotic; this new project will allow us to identify […]
Search Results for: novel
Inhibition of the Myostatin Signaling Pathway in Cultured Muscle Cells by a Novel Small Molecule
Ryan Matekel and Robert Hyldahl, Exercise Sciences Introduction Muscle wasting is a symptom of cancer, AIDS, renal failure, heart failure, aging, prolonged bed rest, and has been seen in rodent models for burn, and kidney disease (Han, 2013). Muscle wasting negatively impacts quality of life by decreasing functional independence and increasing morbidity and mortality (Anker, […]
Utilization of the TGF-β signaling pathway and cell-substrate interaction in a novel anti-cancer drug screen
Nicholas Saguibo and Dr. Marc Hansen, Physiology and Developmental Biology Introduction The TGF-β signaling pathway has been researched extensively over the past few years, and has been shown to be active in the majority of metastatic tumors. Interestingly, tumors expressing TGF-β activity are positively correlated with poorer prognosis in patients, making it a logical target […]
Ceramides, Mitochondrial Fission, and Reactive Oxygen Species, A Novel Mechanism of Obesity-induced Insulin Resistance
Braden Tucker and Dr. Benjamin Bikman, Physiology and Developmental Biology Introduction: With the unabated rise in obesity in the United States and globally (1), increasing efforts are being devoted to understand and prevent both the onset and the consequences of excess fat gain. As evidenced by health trends, efforts to curtail weight gain have proven […]
Genome Annotation of Novel Viruses and Discovery of Critical Sequences in Genes Via Comparative Analysis of B4 Mycobacteriophage
Cameron Sargent and Dr. Sandra Burnett, Microbiology and Molecular Biology Introduction Over the past few years at Brigham Young University and other colleges nationwide, members of the Phage Hunters program have endeavored to find and analyze novel mycobacteriophage in an attempt to create new treatment and research methods for the pathogen Mycobacterium tuberculosis. Not only […]
Comparative Genome Analysis of Novel Paenibacillus larvae Bacteriophage
Bryan Merrill and Dr. Sandra Burnett, Department of Microbiology and Molecular Biology Introduction Honey bees pollinate one third of the crops in the U.S. diet. The spore-forming bacterium Paenibacillus larvae causes American Foulbrood (AFB), a highly contagious disease that is lethal in honey bee larvae. P. larvae is the most serious pathogen affecting honey bees. […]
The Children’s Literacy Project: Classic Literature as a Graphic Novel
Joshua Talbot and Professor Robert Barrett, Illustration In the fall of 2011, my fellow classmates and I decided to create a graphic novel anthology of classic literature as an encouragement for young children to read great, time-tested writing (I decided on Treasure Island). The following is my continued experience on this project, the project’s outcomes and […]
Search for Genomic Factors that Influence Cerebrospinal Fluid Levels of YKL40, a Novel Biomarker for Alzheimer’s Disease
Mo Lee and Dr. John S.K. Kauwe, Biology Department Alzheimer’s disease is the most common form of dementia in the United States. It is a complex neurodegenerative disorder featured by gradual onset and progression of memory loss combined with deficits in executive functioning, language, visuospatial abilities, personality, behavior and self-care. There are basically two types […]
Novel Nanoinjection of Yeast Artificial Chromosomes in Mouse Zygotes
Jordan Kitchen and Dr. Sandra Burnett, Micro and Molecular Biology Transgenic mice are used to create animal models and are typically generated by the addition of transgenes (4-14 Kb pairs) or artificial chromosomes (150-300 Kb) to the pronucleus of a fertilized mouse egg [1][2]. Because of the size of chromosomes, using them to produce transgenic […]
Finding Novel Variants in APP, PS1 and PS2, that alter Gene Functionality and Lead to Familial Alzheimer’s Disease
Matthew Cable-Fabiszak and Dr. John Kauwe, Biology Department Review of Purpose of Project The planned objective of this mentored research opportunity was to identify families in the Cache County Aging Study that harbored mutations in three specific genes known to cause familial Alzheimer’s disease: APP, PS1, and PS2. This knowledge would have been beneficial because […]
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