Camille Nuttall and Kathryn Cabbage, Communication Disorders Introduction Children with dyslexia and children with speech sound disorder exhibit differing issues in regard to their speech and language. Dyslexia is a difficulty decoding written language, such as with word recognition or spelling. Speech sound disorder is characterized by speech production errors. Although dyslexia and speech sound […]
Search Results for: mechanisms
The Effects of Hyperlipidemia on β-Cells
Andrew Barlow, Trevor Lloyd, Mason Poffenbarger, Austin Ricks, Dr. Jeffery Tessem; Nutrition, Dietetics, and Food Science Introduction Diabetes’ prevalence is increasing at an alarming rate. Normally, insulin-secreting β-cells in the pancreas regulate proper glucose absorption and storage. Type 1 and Type 2 diabetes are characterized by decreased functional β-cell mass and insulin production (1). Diabetes also results […]
Histone Post-Translational Modifications and Nucleosome Positioning: A New Layer in the Histone Code Hypothesis?
Andrew Earl and Dr. Steven Johnson, Microbiology & Molecular Biology Introduction Nucleosomes are the fundamental unit of chromatin organization. They consist of an octamer of histone proteins (two of each H2A, H2B, H3, and H4) wrapped around by 147 base pairs of DNA. Their positioning and occupancy around important genetic elements such as enhancers and […]
Modeling Main Group Metal Alkane Functionalization Reactions in Highly Acidic Carboxylic and Sulfuric Acid Solvents
Lily H. Carlson, Prof. Daniel H. Ess, Chemistry Department Our group is interested in identifying the unknown mechanisms of main-group C-H functionalization reactions. In the long term, our goal is to use computational chemistry tools to develop general principles on mechanisms, intermediates, reactivity, and selectivity for hydrocarbon C-H functionalization reactions by p-block main-group compounds as well […]
Seeing the World Through Humility-tinted Glasses: Exploring Social Cognitive Explanations for Outcomes of Humility
Chayce Baldwin and Dr. Robert Ridge, Psychology In recent years, psychological research on humility has burgeoned, highlighting the influence of humility in prominent aspects of life such as well-being (Toussaint & Webb, 2017), interpersonal relationships, and prosocial behaviors (Hilbig, Zettler, & Heydasch, 2012), as well as self-control (De Vries et al., 2013). Particularly, studies have […]
Iron Dysregulation induced by Oxidative Stress is Prevented by Curcumin in C2C12 Skeletal Muscle Cells
Jacob Anderson, Dr. Chad Hancock; Nutrition, Dietetics, and Food Science Introduction Recent studies indicate a correlation between iron dysregulation and insulin sensitivity, suggesting that iron dysregulation may play a role in the development of type 2 diabetes mellitus [1]. However, the connection between iron regulation and insulin sensitivity is not fully understood. Iron is normally tightly regulated, and […]
The effect of Nr4a3 on functional Beta Cell Mass
Jeffery S. Tessem, Nutrition, Dietetics, and Food Science Evaluation of academic objectives The academic objectives of this Mentoring Environment Grant (MEG) were to 1) train undergraduate students in the scientific process to prepare them in careers as physicians and scientists, and 2) to determine if the in vitro phenotypes observed in Nr4a3 deficient beta cell […]
Learning History: Understanding and Facilitating Improvement in Clinical Microsystems
Dr. Bret Lyman, Nursing Department Evaluation of Academic Objectives The academic outcomes of the proposal were generally met (and exceeded). The proposal specified that four students would be involved in the mentoring environment, yet we found it possible to include eight students in faculty-mentored research efforts. Although only three students applied for ORCA grant funding […]
Glutathione-Mediated Oxidative Response in UVB-Irradiated HaCaT Cells
Patrick Badger and Dr. Jason Hansen, Department of Physiology and Developmental Biology Introduction Ultraviolet light (UV) plays a critical role in the etiology of skin cancer, contributing to over 95% of both melanoma and non-melanoma diagnoses. It consists of several wavelengths, among which UVB is the most harmful, causing inflammation associated with sunburn and constituting […]
Ceragenins as antimicrobial agents against Candida auris
Brian Hilton and Dr. Paul Savage, Department of Chemistry and Biochemistry Antimicrobial resistance has increasingly become a global concern. The World Health Organization classified antimicrobial resistance as a “serious threat [that] is no longer a prediction for the future, it is happening right now in every region of the world and has the potential to […]
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