Nielson, Chris Creation of Twelve Member Plasmid Library for Promoter Swapping to Control Chromosomal Gene Expression in E. Coli Mentor: William R. McCleary, Department of Microbiology and Molecular Biology Introduction Metabolic engineering is becoming a very important area of research, allowing researchers to harness metabolic pathways to either eliminate or synthesize desired compounds. Understanding metabolic […]
Search Results for: expression
Examining Gene-Expression Patterns Across Rare Colon Cancer Syndromes to Identify Early Diagnosis and Treatment Options
Hawkes, Douglas Examining Gene-Expression Patterns Across Rare Colon Cancer Syndromes to Identify Early Diagnosis and Treatment Options Faculty Mentor: Stephen Piccolo, Biology Introduction Colon cancer often runs in families. Individuals in these families have a relatively high lifetime risk of developing colon cancer and often develop aggressive tumors at a relatively young age. Currently, genetic […]
The Role of BDNF Expression In Chronic Ethanol Usage
Porter, Caleb The Role of BDNF Expression In Chronic Ethanol Usage Faculty Mentor: Scott Steffensen, Neuroscience Introduction It has been observed that chronic exposure to drugs of abuse, particularly opiates, increases brain-derived neurotrophic factor (BDNF) levels in ventral tegmental area (VTA) neurons. In particular, BDNF expression is dramatically increased during drug withdrawal, which would suggest […]
How Well Can Machine-learning Algorithms Predict Biomedical Outcomes Based on Gene-expression Data?
Anna Guyer and Stephen Piccolo, Department of Biology Introduction Biomedical data are increasing in size and complexity. To make sense of these data, biomedical researchers often use “machine-learning” algorithms, which are developed by the computer-science community. Our goal was to perform a systematic comparison of many of these algorithms across 100 data sets to identify […]
Novel G-protein Coupled Receptor Expression and Modulation of Synaptic Plasticity
Michael Thayer Christensen and Dr. Jeff Edwards, Physiology and Developmental Biology Introduction According to the Centers for Disease Control and Prevention, Alzheimer’s disease – infamously known for its patients’ loss of memory and other intellectual abilities – is the sixth most common cause of death in the United States. Sadly this is just one of […]
The Effect of Promoter Region Indels on Expression Bias in Polyploid Cotton Species
Zachary Liechty and Joshua Udall, Plant and Wildlife Sciences Many plants undergo polyploidization events throughout their history, meaning their genome doubles1; the goal of this project was to identify how these polyploidization events lead to changes in gene expression on a nucleotide level. Polyploidization events provide raw material to be acted upon by natural selection, […]
Creation of an Eight-Member Plasmid Library For Promoter Swapping to Control Chromosomal Gene Expression in E. Coli
Matt Phillips and Dr. William McCleary, Microbiology and Molecular Biology I. Introduction The ability to control gene expression in bacteria has been essential in solving problems in many fields, including medicine and environmental protection. Recent advances in genomic and metabolic modeling tools have led to the development of a new technique called promoter swapping which […]
Ventral tegmental area dopamine and GABA neurons: Physiological properties and expression of mRNA for endocannabinoid biosynthetic enzymes and type I metabotropic glutamate receptors
Zachary Hopkins and Jeffrey G. Edwards, Department of Physiology and Developmental Biology Introduction The ventral tegmental area or VTA is considered to be one of the foremost centers involved in motivation and reward processing in the brain [1]. This area is also heavily implicated in addiction. However, little is known in regards to the exact […]
Novel Comet Assay Identifies Preliminary DNA Damage Prior to Cell Apoptosis in Mouse Model of RAGE Over-expression
Steven Knapp and Paul Reynolds, PDBIO Introduction The goal of this project was to characterize the predisposing susceptibility of mice that overexpress receptors for advanced gylcation end products (RAGE) to apoptosis (cell death) and autophagy. Work has already been done to characterize this mouse model as pro-apoptotic; this new project will allow us to identify […]
Histone Modifications and their Effects on Nucleosome Positioning and Gene Expression
Jordon Ritchie and Steven Johnson, Department of Micro and Molecular Biology Introduction Nucleosome positioning plays an important role in gene regulation and expression. Nucleosomes consist of DNA-histone interactions that comprise the first order of DNA compaction into chromatin in the cell. Modifications to the histone in the nucleosome have been hypothesized to influence the location […]
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