John Kauwe, Biology Project Justification and Overview Successful enrollment in and completion of graduate programs requires a constellation of skills. Students must be prepared to plan and execute experiments, present their findings both verbally and in manuscript form and interact effectively with senior scientists in the field of their choice. In this MEG I will […]
Search Results for: disease
T Cell Immunotherapy of Infection Disease and Cancer
Scott Weber, Microbiology and Molecular Biology 1) Project Summary This project was focused on improving the immune response to infectious disease and cancer. We have engineered T cell receptors with 1000-fold increase in affinity and will characterize their value as diagnostics and therapeutics. In addition, we examined changes in T cell function due to the […]
Chemokine Receptor CCBP2-V41A and its Role in Inflammation and Alzheimer’s Disease
Allen Weinert and Scott Weber, Microbiology & Molecular Biology Introduction The leading cause of dementia in elderly patients is Alzheimer’s disease (AD), a degenerating and fatal neurodegenerative condition. AD is a proteopathic disease caused by extensive accumulation of amyloid beta plaques and neurofibrillary tangles. A recent genomewide association study analyzing 59 AD-associated cerebrospinal fluid (CSF) […]
Characterization of Mutant Chemokine (C-C) motif Receptor-Like 2 (CCRL2) and its Role in Inflammation and Alzheimer’s Disease
Meganne Ferrel and Dr. John S. K. Kauwe, Biology Introduction Alzheimer’s Disease (AD) is identified as a proteopathic disease that results from an extensive accumulation of amyloid plaques and neurofibrillary tangles in the brain. Several researchers have discovered that cerebrospinal fluid (CSF) contains biomarkers for AD such as Amyloid-beta and tau. Neuritic plaques in AD […]
Clinical vs Neuropathological Diagnosis in Alzheimer’s Disease Research
Gage Black and John S. K. Kauwe, Biology Introduction Alzheimer’s Disease (AD) is the most common form of dementia and affects millions of people worldwide. It is the 6th leading cause of death in the United states and the only disease in the top 10 causes of death that does not have a disease altering […]
Cell Free Single Stranded DNA Concentration in CSF as biomarker to diagnose Alzheimer’s Disease
Taylor Avei and Dr. John Kauwe, Biology Introduction: The neuropathology of Alzheimer’s Disease (AD) is well-known as a degradation of neural connections in the brain caused by multiple deposits of Amyloid-beta peptide plaques as well as neurofibrillary tangles of tau proteins [1]. Because of this and successful research, both Amyloid-beta 42 and tau protein levels […]
Association of Essential Tremor and Parkinson’s Disease Development
Alexander Gosch and Faculty Mentor: Mary David, Molecular and Microbiology Introduction Essential tremor (ET) is a neurological disorder characterized by symmetrical tremor of the upper limbs. Parkinson’s disease (PD) is a similar disorder, also characterized by tremor, with a few differences: ET tremor is mostly seen during action, while PD tremor is more prevalent while […]
Characterizing endophyte interactions that enhance tolerance of water stress and disease in economically and culturally important succulent crops, Agave and Yucca
Claire Poore and Faculty Mentor: Ryan Stewart, Plant and Wildlife Sciences Introduction Agave and Yucca species are both cultural and economically important in the south western United States and Mexico. As desert plants, Agave and Yucca have adapted to hot and dry conditions and with increasing global temperatures, have the potential to fill even more […]
RAB10: The Future of Alzheimer’s Disease
Keni Reid and Dr. John Kauwe, Biology Department Alzheimer’s disease is a brain disorder caused by an irreversible degeneration of nerve cells. It is developed in response to a growth of proteins, tau tangles or amyloid plaques, which disrupt communication between neurons in the brain. Because the nerve cells no longer function, they die. It […]
BYU undergraduates validate novel genetic variants that protect from Alzheimer’s disease
John S.K Kauwe BYU undergraduates validate novel genetic variants that protect from Alzheimer’s disease Project Justification and Overview Successful enrollment in and completion of graduate programs requires a constellation of skills. Students must be prepared to plan and execute experiments, present their findings both verbally and in manuscript form and interact effectively with senior scientists […]
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