Bratsman, Andrew The Effect of Gut Microbiota on Cancer Metastasis in Model Organism D. Melanogaster: Establishing an Abnormal Genetic Line of D. Melanogaster Faculty Mentor: Prof. John Chaston, Plant and Wildlife Sciences Introduction As early as the beginning of the 20th century, Metchnikoff proposed that putrefactive bacteria living in the digestive tracts of hosts contribute […]
Search Results for: cancer
Identifying the Upstream Target of Resveratrol in Breast Cancer Cells
Jeffrey Mecham and Jason Kenealey; Department of Nutrition, Dietetics, & Food Science Introduction One commonly disrupted pathway in many different cancer cells lines revolves around the tumor suppressor protein p53. Approximately half of human cancers exhibit direct, inactivating mutations of p53, while the majority of the remainder either elevate inhibitors, reduce activators, or deactivate downstream targets […]
Communication Patterns, Spousal Influence, Relationship Quality, and Genetic Testing in Regards to Colorectal Cancer Prevention
Kaitlynn Wright and Wendy C. Birmingham, Department of Psychology Introduction Colorectal cancer (CRC) is one of the most common cancer types in the United States. Having CRC in one’s family history is one of the strongest risk factors for this cancer, suggesting a genetic influence in developing CRC. While this cancer can be deadly, many […]
An Examination of Relationship Processes on Cancer Screening Decisions in Married Couples
Wendy Birmingham, Psychology Review of Research Study and Academic Objectives Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer death in the U.S. A family history of CRC is one of the strongest risk factors for the disease; those with a first-degree relative (i.e., a parent, sibling or […]
Targeting Superoxide Dismutase-1 in Cancer
Laura Oh and Josh Andersen, Department of Chemistry and Biochemistry Introduction SOD1 is overexpressed in many cancers such as lung adenocarcinoma, non- small-cell lung cancer, and 70% of primary breast cancers. Traditionally, SOD1 is known as an antioxidant in the human body, but only 1% of SOD1 expressed in cells is necessary to keep superoxide […]
Role of the Viral LANA Protein in Human Cancers caused by Kaposi’s Sarcoma-Associated Herpesvirus
Gregory Low and Brad Berges, Microbiology and Molecular Biology The purpose of our experiment was to ascertain the importance of the LANA protein encoded by the Kaposi’s Sarcoma-Associated Herpesvirus (KSHV). LANA is believed to be essential for the survival of KSHV in human cells. KSHV causes a variety of cancers including Kaposi’s sarcoma (KS), multicentric […]
An Examination of the Relative Accuracy of Family Cancer History Knowledge and Perceptions of Spousal Influence in a Younger Population
Emily Hartung and Wendy Birmingham, Psychology Introduction Cancer is the second leading cause of death in the United States, yet many people are not aware of their own personal familial risk. This may be especially true in younger individuals in the population. According to the American Cancer Society, over 1.5 million Americans will be diagnosed […]
Interest in Genomic Testing Among Individuals at Increased Risk for Colorectal Cancer
Jordan Sgro and Wendy Birmingham, Psychology Introduction CRC is the third leading cause of cancer death in the U.S. Despite the fact that screening can detect CRC earlier and lead to better outcomes, screening adherence remains less than optimal in individuals with increased family risk. Identifying the genetic causes of moderate increases in CRC risk […]
Optimization of Selenium Chemoprevention in Prostate Cancer Cells
Xiuqi Li and Merrill Christensen, Nutrition, Dietetics, and Food Science Introduction Prostate cancer is the most frequently diagnosed cancer and the second-leading cause of cancer death in men in the United States (1). However, most men will die with prostate cancer rather then from it (2). Because prostate cancer exhibits a long latency period, high […]
Utilization of the TGF-β signaling pathway and cell-substrate interaction in a novel anti-cancer drug screen
Nicholas Saguibo and Dr. Marc Hansen, Physiology and Developmental Biology Introduction The TGF-β signaling pathway has been researched extensively over the past few years, and has been shown to be active in the majority of metastatic tumors. Interestingly, tumors expressing TGF-β activity are positively correlated with poorer prognosis in patients, making it a logical target […]
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