Kimberly Clemons and Dr. Joshua Udall, Plant and Wildlife Sciences Introduction The purpose of the copy number variation (CNV) project was to determine if there is a variation in the DNA content between tissue types of Gossypium hirsutum and Gossympium barbadense. Specifically if the cotton fiber cells contain CNV that contribute to the increased output […]
Archives for May 2015
Social Cognitive Predictors of Residential Radon Testing and Mitigation
Siena Davis and Dr. James Johnston, Health Science Introduction In the U.S., exposure to radon gas (222Rn) is the second leading cause of lung cancer after tobacco smoke.(1) 222Rn is a naturally occurring environmental carcinogen produced during the radioactive decay of uranium-238, which is found in many soils throughout the U.S.(2) Because 222Rn is a […]
Mapping Interaction Through Compensatory PhoU Mutants in Escherichia Coli
Tanner Dean and William McCleary, MMBIO Introduction The purpose of this experiment was to identify the physical interaction site between two proteins in Escherichia Coli. These two proteins, PhoU and PhoR, are two proteins involved in Phosphate signal transduction. When these two proteins are mutated, so they no longer interact, the pathway is broken and […]
Mapping the Trigeminal Nerve
Kinnison Edmunds and Dr. Jonathan Wisco, Department of Physiology and Developmental Biology Introduction The goal of my project was to create a data-driven, three-dimensional map of the human trigeminal nerve from the trigeminal ganglion to the ends of its major pathways throughout the face and head. The purpose was to test conventional wisdom regarding the […]
Microarchitectural Analysis of the Ulnar Collateral Ligament to Inform its Reconstruction
Jakob Gamboa and Dr. Jonathan Wisco, Physiology and Developmental Biology Ligaments are specialized connective tissues that stabilize the different synovial joints found in the body. Ligaments consist of fibroblast cells surrounded by a framework of dense fibrous bands of collagen, which anchor to bones to provide support and elasticity. Their varying biomechanical functions in different […]
Customizing 3D models from MRI data: Creating educational anatomy models of neurologic disease
Brett Gardiner and Dr. Jon Wisco, Department of Physiology and Developmental Biology Introduction Neuroanatomy lab specimens are limited to cadaver availability and inconsistently demonstrate variations confronted in pathology. Using rapid prototyping (RP) technology to create 3D models from segmented MRI data offers distinct benefits to medical education. An efficient and replicable procedure for customizing these […]
Analysis of Anti-Dengue Antibodies
Lauren Syndergaard and Brian Poole, Micro and Molecular Biology Introduction Dengue virus is a mosquitoes-borne virus that causes dengue fever. It is found primarily in tropical areas with over a third of the world’s population living in at-risk areas (WHO). The number of infections has grown rapidly in recent years with as many as 50 […]
Rare Genetic Variant to the Protection of Alzheimer’s Disease
Josue David Gonzalez Murcia and John Kauwe, Biology Department Introduction Alzheimer’s disease is one of the top 10 causes of death in the world and the 6th leading cause of death in the United States, with 5.5 million people diagnosed with the disease. Alzheimer’s cannot be cured, prevented or slowed. Most research with Alzheimer’s disease […]
Use of humanized mice to study the production of human antibodies
Steven Hallam and Dr. Bradford Berges, Microbiology and Molecular Biology Introduction The human immune system is composed of two main subsets: innate and adaptive immunities. Among the adaptive immune cells, B cells play a vital role in stopping infectious agents through the production of antigen specific antibodies. Human B cells are important targets of infection […]
Engineering a Pathogen Specific High Affinity T-Cell Receptor Called LLO56
John Hancock and Dr. Scott Weber, Department of Microbiology and Molecular Biology Introduction CD4+ helper T-cells play a vital role in the body’s immune response. When infectious agents attack the body, phagocytes engulf these invaders and present a peptide segment of the pathogen on a receptor (called MHCII). These receptors are located on the surface […]
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