Cecilia Fernandez and Dr. Gene Cole, Department of Health Sciences Research Objective To conduct an initial needs assessment relative to the promotion of healthy home environments and asthma risk reduction, with a focus on multi-family dwellings and ethnic minority populations (primarily Hispanic). Background Previous studies have shown that ethnic populations, including Hispanics, are prone to […]
Development of Humanized Mice as a Model for the Study of Neuro-AIDS
German Cuadra and Dr. Bradford Berges, Department of Microbiology and Molecular Biology Our main goal of this project was to document the existence of human macrophages in the brain of humanized mice. After the accomplishment of this goal, we planned to infect humanized mice with HIV and find out if these human macrophages support infection […]
PhoU Localization In Escherichia Coli
Austin Callison and Dr. William R. McCleary, Department of Molecular/Microbiology Proposed Project Just as simpler systems are studied to better understand more complex systems, E. coli has long been a standard for biological experiments aimed at a more complete comprehension of the mechanisms that propitiate cell life. One of these vital mechanisms in E. coli […]
The Role of Nectin In Zyxin Localization
Jace Bullard and Dr. Marc Hansen, Department of Physiology & Developmental Biology Abstract A major difficulty of treating cancer rises from its ability to metastasize. During metastasis, strong adhesions between cells break, allowing individual cells to separate and migrate to different locations in the body. Strong cell-cell junctions are formed by protein interactions between actin […]
Selenium’s Effect on Insulin Resistance
Scott Brunson and Professor Chad Hancock, Department of Nutrition, Dietetics, and Food Science Background Due to dramatic increases in type II diabetes, studies on insulin resistance are especially applicable to this current health issue. Previous epidemiological studies examining selenium’s effect on prostate cancer observed a possible correlation between increased risk for type II diabetes mellitus and […]
Biophysical Cell Membrane Changes During Chemotherapeutic Drug-Induced Apoptosis
Amanda Berbert and Dr. John Bell, Department of Physiology and Developmental Biology Overview Our project provided us the opportunity to gain insight into how chemotherapy drugs affect the cell membrane and how secretory phospholipase A2 (sPLA2) can work in tandem with these drugs to accelerate the cell death process. The enzyme sPLA2 produces a pro-inflammatory […]
Determining the effect of Toll-like Receptor-7 on Systemic Lupus Erythematosus Development
Douglas Baumann and Dr. Brian Poole, Department of Microbiology and Molecular Biology Systemic Lupus Erythematosus (Lupus) is an autoimmune disease that afflicts over 250,000 citizens of the United States. Although much remains to be learned about Lupus, the information gathered so far has proven to be extremely valuable in increasing survival rates and improving the […]
A Nuclear Variant of Gdf5 may Present Novel Insights on Arthritis Formation
Michael Baldwin and Dr. Laura Bridgewater, Department of Microbiology and Molecular Biology Introduction More than 40 million Americans suffer from the pains of arthritis. Arthritis is characterized by joint inflammation and cartilage deterioration (3). For many years growth differentiation factor 5 (Gdf5) has been associated with cartilage formation and maintenance (4, 1). GDF5 has been […]
The Effects of Daidumene lineata on the Intertidal Rock Pools
Preston Wilson and Professor Russell Rader, Department of Biology My experiment was to test the effect Diadumene lineata has on the marine life of the intertidal rock pools in the northwest. However, due to unfortunate circumstances there were not any Diadumene Lineata in the area of Coos Bay, Oregon. After discovering that they did not exist […]
Endocannabinoid Biosynthetic Enzymes in Hippocampal Interneurons
Ryan Williamson and Dr. Jeff Edwards, Department of Physiology and Developmental Biology The hippocampus is a region of the brain that mediates learning and memory formation by changing the properties of synapses within its circuitry [2]. The plastic nature of these synapses allows the brain to alter how sensitive one neuron is to stimulation from […]
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