The Role Of Palmitate in Upregulating Nr4a1 and Nr4a3 Proposal Status

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Jordan Tingey and Jeffery Tessem, Nutrition, Dietetics, and Food Science This project focused on the effects of palmitate on transcription factors, Nr4a1 and Nr4a3. All experiments were preformed on a beta cell line. The first experiment was done to show if palmitate effected proliferation of Nr4a1 and Nr4a3 knockout cell lines. This experiment was preformed […]

Discovery and Characterization of Bacteriophage to control MRSA

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Jacob B. Hatch and Bradford Berges, Microbiology and Molecular Biology Introduction About 20% of humans are carriers of Staphylococcus aureus (SA). There were an estimated 11,000 deaths in the United States in 2005 attributed to SA, with the majority caused by MRSA (Methicillin Resistant Staphylococcus Aureus) isolates [1]. Many MRSA isolates have developed resistance to […]

Ligament microstructure analysis

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Michael Gillespie and Jonathan Wisco, Physiology and Developmental Biology Introduction Due to the relatively poor fiber contrast of tendons in comparison with muscles, the anatomical, and therefore, functional relationship of muscle attachments to bones via tendons has not been well mapped. We were interested in mapping the 3D gross anatomical structure of tendons using a […]

Targeting Superoxide Dismutase-­1 in Cancer

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Laura Oh and Josh Andersen, Department of Chemistry and Biochemistry Introduction SOD1 is overexpressed in many cancers such as lung adenocarcinoma, non-­ small-­cell lung cancer, and 70% of primary breast cancers. Traditionally, SOD1 is known as an antioxidant in the human body, but only 1% of SOD1 expressed in cells is necessary to keep superoxide […]

Analyzing structural differences in quadriceps femoris tendon fibers using MicroScribe technology

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Nathaniel Hainsworth and Jon Wisco, Physiology and Developmental Biology Introduction Not all tendons and ligaments are created equally. Many have different structural characteristics based on functionality or need for stability. This turns out to be true even between different portions of the same tendon. This project’s purpose was to analyze and compare structural differences between […]

Three-Dimensional Model of Undocumented Lingual Nerve Branches for the Education of the International Anatomy, Medical, and Dental Population

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Craig D. Clayton and Dr. Jonathan Wisco, Physiology and Developmental Biology The floor of the oral cavity is covered by a mucosal layer to protect underlying structures against the digestive events of the mouth. Ducts of the salivary glands open into this mucosa along the lingual frenulum. The lingual nerve from the mandibular division of […]

Development of a Model to Predict Preadolescent Children’s Indoor PM10 Exposures

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Rebecca Bradshaw and James Johnston, Health Science Department Introduction Asthma is the most common chronic disease among children worldwide, and the third-ranking cause of hospitalization for children under 15 years of age.(1-2) While the exact causes are unknown, studies show that having a genetic predisposition coupled with early-life allergen exposures increases the likelihood of developing […]

Analysis of HMGCR as a Genetic Modifier for Alzheimer’s Disease

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Brian Davis and Dr. John S.K. Kauwe, Biology Introduction Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that occurs predominantly later in life and represents the fourth most common cause of death in the developed world. Given the absence of curative treatment, discovering the factors related to the development of AD and the conversion from […]

Foot Strike Angle Changes During Shod, Minimalist, and Barefoot Running, and Correlation to Injury

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Ani Henriksen and Dr. Sarah Ridge, Biomechanics Introduction Running is a popular form of exercise. With high incidence of injury, runners are always looking for the next cure to stay injury free. Many webpages offer conflicting advice about shoes and foot strike. Although recommendations vary, barefoot running and use of minimalist shoes has increased. With […]

The Efficacy of Neurofeedback Training in Enhancing High-Order Processing in Addicts

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Ian Armstrong and Scott C. Steffensen, Psychology Introduction Biofeedback is a process by which a person learns to control physiological functions of their body that they would otherwise not be conscously aware of. This is accomplished by relaying real-time information back to the user in the form of data or a game. The user then […]