Megan Stogsdill and Dr. Paul Reynolds, Physiology and Developmental Biology Receptors for advanced glycation end products (RAGE) are receptors that can bind a variety of ligands and are members of the immunoglobin family of cell surface receptors. RAGE is found in many tissue types during inflammatory lesions but is found most abundantly in the lung, […]
Development, Characterization and Linkage Mapping of Single Nucleotide Polymorphsim in the Grain Amaranths (Amaranthus spp.)
Scott Smith and Dr. Jeff Maughan, Plant and Wildlife Sciences The grain amaranths (Amaranthus sp.) are important pseudo-cereals native to the New World. During the last decade they have garnered increased international attention for their nutritional quality, tolerance to abiotic stress and importance as a symbol of indigenous cultures. Notwithstanding their renewed potential as an […]
Diagnostic and Therapeutic Potential of the Over-expression of Nucleotide Salvage Pathway Enzymes to the Plasma Membrane of Solid, Cancerous Tumors
Daniel Sharp and Dr. Kim O’Neill, MMBio Immunotherapy is a developing field in cancer treatment that relies upon the bodies natural defenses to target and eliminate cancerous cells. In order for the immune system to differentiate cancerous tissue from normal tissue there must be some mechanism for targeting only cancerous cells. Without a targeting mechanism, […]
Determining the Presence of Micro RNA in the Untranslated Regions of AdipoQ, a Metabolism Gene
Victoria Scott and Dr. John (Keoni) Kauwe, Biology Department Goal/Purpose: The purpose of this project is to sequence the untranslated region of the AdipoQ gene and interrogate it for novel genetic variation and potential microRNA sequences. This work will illuminate how adiponectin levels are regulated and provide insights into type II diabetes, metabolic syndrome, and […]
Increasing Phosphorus Use Efficiency with New Fertilizer Products in a Hydroponic System
Curtis Ransom and Dr. Von Jolley, Plant and Wildlife Science Food production is fundamental to our existence. A major component of modern agriculture is fertilizer, especially in terms of production to meet heavy demands of domesticated crops. Phosphorus (P) is one of the three major fertilizer components, and is known to be a limited resource. […]
The Distribution of the Alpha 5 nAChR Subunits in the Mouse Lung
Jason Porter and Dr. Paul Reynolds, Physiology and Developmental Biology The study of developing tissues is extremely important in the field of biology. Each organ in the body adheres to an extremely complex and organized development process involving specific signaling molecules and pathways. Pulmonary development is no exception. Lung development adheres to intimately orchestrated processes […]
Validation of Genetic Association between Variants in PPP3R1 and MAPT and Rate of Progression of Alzheimer’s Disease
David Peterson and Dr. John S. K. Kauwe, Biology Introduction Alzheimer’s disease (AD) is the most common neurodegenerative disease, affecting more than 4.5 million people in the US. Genetic studies of AD have previously identified mutations in three genes (APP, PSEN1 and PSEN2) and polymorphism in APOE as risk factors. These findings have led to […]
Researching the Effects of Osteoarthritis as a Systemic Immune Response
Danielle Peterson and Dr. David Kooyman, Physiology and Developmental Biology Our bodies are dynamic structures that do not operate as individual compartments, but as a whole. When something goes awry in one specific tissue or organ, specific signals from that diseased area are released affect other tissues. I received an ORCA grant last year to […]
Characterization of the Role of a DNA-Binding Protein on Regulation of DNA Replication in Plant Organelles
Cynthia Perry and Dr. Brent Nielsen, MMBio DNA replication is essential to all life on earth. Not only does replication occur in the nucleus, it also happens in organelles of the cell: the mitochondria and chloroplasts. In higher plants such as Arabidopsis thaliana, the genomes in mitochondria encode proteins which are responsible for DNA replication. […]
Genetic Factors that Influence Tau Protein Levels in CSF and Risk for Alzheimer’s Disease
David Patty and Dr. John SK Kauwe, Biology Alzheimer’s Disease, the most common form of dementia, affects nearly 6 million Americans. Its effects on the individual range from mild impairment of memory to the complete destruction of the victim’s identity and their ability to perform everyday tasks. They become a heavy burden on their family, […]
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