Tacie Hall and Dr. Julianne Grose, Department of Microbiology and Molecular Biology When PAS kinase is knocked out in mice placed on high-fat diets, these mice show such symptoms as decreased weight gain, hypermetabolic phenotype, decreased liver triglyceride accumulation, and retained insulin sensitivity when compared with their wild type littermates.1 These symptoms are highly associated […]
Determining the Role of Kaposi’s Sarcoma-associated Herpesvirus LANA Protein in the Development of Persistent Infection
Jamie Gardiner and Dr. Brad Berges, Department of Microbiology and Molecular Biology Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is a human cancer virus that causes Kaposis’ sarcoma, the most common cancer found in AIDS patients. Our lab is working to develop humanized mice as a novel animal model to study KSHV infection and related diseases, since there […]
The Neuroprotective Effects of Exercise on LTD in the Hippocampus
Adam Field and Dr. Jeff Edwards, Department of Physiology and Developmental Biology In April of 2012, IACUC committee approved the methods which we had set forth for the carrying out of the experiment. At this point we began gathering the tools and materials needed for the performing of the experiment. Mice were obtained, and the […]
Premature Osteoarthritis in the Temporomandibular Joint of Heterozygous Disporportionate Micromelia Mice
Jason Farrell and Dr. Robert Seegmiller, Department of Physiology and Developmental Biology Purpose of the Study The purpose of this study, as also summarized in the proposal for this research grant, was to analyze the temporomandibular joints (TMJs) of mice with a specific collagen defect, Disproportionate Micromelia. Examining these joints was done to provide an […]
Diversification Rates, Phylogenetic Relationships, and Character Evolution within an Ancient Group of Decapod Crustaceans (Anomura: Decapoda)
Maren Ettinger and Dr. Keith Crandall, Department of Biology The purpose of phylogenetics is to understand the evolution of a group of organisms and to resolve the relationships within groups. Once phylogenies are created, they can be used for a number of different analyses. My project focused on using a phylogeny of the infraorder Anomura […]
A Novel Role for AMP-activated Protein Kinase as a Selective Inhibitor of de novo Ceramide Biosynthesis
Kate Erickson and Dr. Benjamin Bikman, Department of Physiology and Developmental Biology The purpose of this project was to determine the cellular mechanisms that mediate AMPK-induced reductions in lipotoxicity. We predicted that AMPK activation inhibits lipotoxic ceramide biosynthesis via targeted reduction in transcription of a critical, rate-limiting enzyme involved in de novo ceramide synthesis. This […]
CASTing for a Putative DNA Binding Sequence for nBmp2
Brian Earley and Dr. Laura Bridgewater, Department of Microbiology and Molecular Biology Bmp2 is a secretory mammalian protein that plays important roles in bone development and adult pathology. Recently, a nuclear variant (nBmp2) was discovered with an unknown function for this typically secretory protein in the nucleus (Felin et al., 2010). The purpose of this […]
Novel and Integrative Approaches to Articulating the Pancrustacean Tree of Life
Alan Colver and Dr. Keith Crandall, Department of Biology The taxonomic group Pancrustacea encompasses more than half of the world species. The two main groups within Pancrustacea are the crustaceans and hexapods (insects). Understanding these two groups will aid in preservation, population control, and economic pursuits involving these groups. In our evolutionary analysis, six different […]
Validation of Possible Blood Serum Biomarkers Linked to Genetic Risk of Alzheimer’s Disease
Jesse Cobell and Dr. John Kauwe, Department of Biology Importance of the Project In 2011, the Alzheimer’s Association released in their annual facts and figures that 5.4 million people suffer from Alzheimer’s disease. Alzheimer’s is the sixth leading cause of death in the United States and is the only disease in the top ten that […]
Examining Quantitative Differences in Gait Between the PVC Prosthesis Design and the Traditional Prosthesis
David Chinn and Dr. Matt Seeley, Department of Exercise Sciences Our purpose in conducting research was to evaluate a novel, below-knee PVC prosthesis (Figure 1) relative to traditional below-knee prostheses. We aimed to collect data from the biomechanical gait analysis of amputees using the PVC prosthesis. Our desire is to help those in developing nations […]
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