Christopher M. Lee and Dr. G. D. Watt, Chemistry and Biochemistry Ammonia is extremely valuable in the industrial production of fertilizer, plastics, explosives, dyes, and other compounds. The most plentiful and common source of ammonia comes from the conversion of atmospheric nitrogen gas to ammonia. In industry the 80-year-old Haber method is used, which is […]
Kurasoin B Analogues
Jason Nielson and Dr. Merritt Andrus, Chemistry and Biochemistry During the past year, I have actively worked at developing analogues of the anti-cancer agent kurasoin B. I have included the synthetic path that we have followed during the past year as a reminder of the proposed plan I submitted. Included in the general synthetic pathway […]
Finding Interactions between SmpB and tmRNA during Trans-translation
David Healey and Dr. Allen Buskirk, Chemistry and Biochemistry During the last year, I have worked in collaboration with Allen Buskirk and DeAnna Cazier to study the interactions between SmpB and tmRNA during a process called bacterial trans-translation. To understand our experiments, it is necessary to know a little about what trans-translation is, and how […]
Effects of Metabolic Rate on Muscle Cell Phospholipid Profile
Aaron Miller, Danny Sims, and Dr. Steven Wood, BYU Department of Chemistry and Biochemistry Animal and human cell membranes are composed primarily of phospholipids that form a bi-layer around the cell. Phospholipids play a crucial role in cell membrane function by regulating fluidity and structure. Alterations in the cell membrane composition can drastically affect cell […]
Diversity of HIV
Jacob Venesky and Dr. Greg F. Burton, Department of Chemistry and Biochemistry My ORCA research project was designed to assess the level of diversity found in a patient’s body. When a doctor prescribes drugs to combat HIV, he or she must first assess whether the patient houses drug-resistant strains. This is usually done by extracting […]
Strategic Isolation of a Putative COX Enzyme Honors Thesis
Jacob Orme and Dr. Daniel Simmons, Department of Chemistry and Biochemistry Most of the results of my work are confidential pending publication. This also applies to the public availability of my honors thesis, which will not be printed until later this year as a result. This fact highlights two important points: 1) I will be […]
Optimization of Anti-Cancer Agents Discovered at BYU
Chris Cutler and Dr. Matt Peterson, Chemistry Summary The goal of this project was to prepare a library of adenine-based anticancer agents in order to help understand which properties of the molecules contribute to the anticancer activity. I worked in Dr. Peterson’s organic chemistry laboratory for the duration of 2009, synthesizing compounds for anticancer testing. […]
Total Synthesis of 12-HETE using Asymmetric Phase-transfer Catalyst
Adam Calvert and Dr. Merritt Andrus, Chemistry and Biochemistry Natural compounds can be found throughout the world in an essentially limitless variety. By discovering compounds and investigating their properties, we can unlock the mysteries to cure rare diseases and alleviate common ailments. There are however many challenges with using natural compounds in such ways. The […]
Synthesis of (S)-Equol
Aaron Butler and Dr. Merritt Andrus, Department of Chemistry and Biochemistry S-equol is a soy isoflavone metabolized from the isoflavone daidzein by intestinal microflora. Isoflavones are a class of nonsteroidal estrogens. A study conducted by DellaPenna indicates that populations with isoflavone-rich diets have fewer incidences of cardiovascular disease, osteoporosis, and some cancers including breast, prostate, […]
ORCA Report
Jacob Voelkel As a researcher in the Dearden Lab, I researched the selective binding properties of metal ions to members of the cucurbituril family. We developed procedures to introduce molecular gases to nanostructures that could be used to enhance neuro-magnetic resonance imaging. We were the first group to introduce gasses such as krypton and xenon […]
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