Dr. Morris J. Robins and Dr. Theodore C. Jessop, Chemistry and Biochemistry 2-amino-6-alkoxypurineribosides are involved in clinical testing as anticancer co-drugs (1); however, current methods for the large scale synthesis of these compounds have proven extremely difficult. The improved synthesis of 2-amino-6-alkoxypurineribosides reported herein allows easy access to these medicinally important compounds. The novel reaction […]
Search Results for: synthesis
The Synthesis of Lipid A Analogs for Use in Studying the Binding of Lipid A and Polymyxin B
Paul B. Savage and Dr. Bryce A. Harrison, Chemistry and Biochemistry Gram-negative bacteria contain a toxin known as lipid A (1 in Figure 1). During bacterial infections, lipid A may be released from the bacteria and cause a condition known as septic shock, an over-response of the host immune system that may result in death […]
Synthesis and Characterization of Novel Amino-Retinoid A4-Spermine
Jeffrey Swallow and Dr. Heidi Vollmer-Snarr, Chemistry Age Related Macular Degeneration (AMD) is the leading cause of vision loss in developed countries. The accumulation of lipofuscin in the eye causes death of the retinal pigment epithelium (RPE) leading to blindness (1,2). The lipofuscin chemical A2E has been shown to have cytotoxic effect in RPE, yet […]
Retinal-bio-amine Synthesis Related to Age-related Macular Degeneration
Matthew Sparks and Dr. Heidi Vollmer-Snarr, BYU Chemistry Department Age-related Macular Degeneration (AMD) is the leading cause for blindness among the world’s elderly population1. As the central region of the retina, known as the macula, is damaged and begins to deteriorate, central vision becomes clouded. This vision loss progresses until the affected person becomes completely […]
Synthesis of HIV Integrase Inhibitors
Carl Jones and Dr. Matt A. Peterson, Chemistry We have made significant progress toward the synthesis of one branch of the library of compounds that we plan to synthesize. The scheme we have followed is shown below. Once synthesized, we plan to have the compounds tested by expert collaborators to see how well they bind […]
Total Synthesis of the Natural Product Hasubanonine
Spencer Jones and Dr. Steven Castle Abstract Hasubanonine is a tetracyclic alkaloid with potential analgesic activity. The total synthesis of this alkaloid has been undertaken in order to demonstrate the applicability of the methodology developed for the synthesis of acutumine and to assay the potential medicinal activity of the compound. The key steps in the […]
Synthesis of HIV integrase Inhibitors
Carl Jones and Dr. Matt Peterson, Department of Chemistry and Biochemistry The ultimate goal of this project is to synthesize a library of compounds designed specifically to inhibit HIV integrase. HIV integrase is the enzyme that incorporates viral DNA into host DNA. Currently, there are no FDA approved inhibitors of HIV integrase. This makes it […]
Copper Nanowire Synthesis by Electroless Deposition
Adam Washburn and Dr. Adam Woolley, Chemistry and Biochemistry Project Background The construction of nanometer-scale electronic devices is an emerging and promising interdisciplinary field. Nanoelectronic devices may reduce size limits in integrated circuits and also function as miniature chemical detectors.1 Nanowire connections are essential components of nanoelectronic devices. A recently developed method for creating nanowires […]
SOLID PHASE SYNTHESIS OF THE PEPTIDE HULHV AND CHARACTERIZATION USING NUCLEAR MAGNETIC RESONANCE
Matthew J. Hinton and Dr. Roger G. Harrison, Chemistry and Biochemistry An exciting area of research is based on the idea that small molecules can be used to perform the same chemical reactions as enzymes. In living organisms, enzymes play important roles in facilitating the vast majority of biochemical reactions necessary for life. One particular […]
SYNTHESIS OF LIPID A ANALOGS FOR USE IN STUDYING THE BINDING OF LIPID A AND POLYMYXIN B
Bryce A. Harrison and Dr. Paul B. Savage, Chemistry and Biochemistry Lipid A (1 in Fig. 1) is a bacterial compound that can cause sepsis, an overreaction of the immune system during bacterial infections.1 Because no good treatment is known, sepsis causes over 100,000 deaths annually in the U.S.1 Treatments for sepsis are difficult to […]
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