Kristen Alexander and Dr. Marc Hansen, Physiology and Developmental Biology A key characteristic of cancer is metastasis of the primary tumor to other locations in the body. Hepatocyte-growth factor (HGF) is a highly characterized and studied factor that induces epithelial cell scattering, through the c-met pathway, and mediates a similar response to metastasis (Cecchi, et […]
Search Results for: regulation
A Functional Assay to Measure Chemokine Mediated Integrin Upregulation
Victoria Harris and Dr. Eric Wilson, Department of Molecular Biology and Microbiology The presence of IgA antibody secreting cells (ASCs) in mucosal tissues is a mechanism of host defense against many pathogens. For my project I investigated the molecular mechanisms of how these specialized cells arrive at their destination. I focused on designing an adhesion […]
Hormonal Regulation of Brain Calcium-Binding Proteins During the Rat Estrous Cycle
Joseph M. Thompson and Dr. Edwin D. Lephart, Zoology Calcium plays a major role in the body; it’s involved in bone growth, muscle contraction, and especially in the central nervous system (CNS) development and function. However, an overabundance of calcium leads to cell degeneration and eventually cell death, disrupting the formation of synapses. The body […]
Selenium-Regulation of Steroid Hormone-Mediated Gene Expression in Transformed Human Prostate Epithelial Cells
David R. Nielsen and Dr. Merril Christensen, Food and Science and Nutrition Introduction Prostate cancer is the second leading cause of cancer-related deaths in American men, with current estimates projecting 179,300 new cases and 37,000 deaths this year [1]. The development of prostate cancer may be divided into three stages: initiation, promotion, and progression. During […]
Distribution and Regulation of Na,K-Atpase in Ocular Lens
Adam L. Lunceford and Dr. Steven W. Graves, Chemistry and Biochemistry The Na,K-ATPase is a membrane-bound enzyme found in all cells. This enzyme is composed of an a subunit, which is responsible for the enzyme’s catalytic activity, and a b subunit, which assists in the binding of ions. The three main isoforms of the a […]
Regulation of G-Protein Signaling by Phosducin-Like Protein
Steven M. Bray and Professor Steven M. Bray, Chemistry and Biochemistry Introduction and Project Aim G-protein signaling is one of the major pathways which cells utilize to transmit messages. The signaling pathway consists of a receptor coupled to a G-protein, which activates secondary messengers. Signaling molecules, such as hormones and neurotransmitters, bind receptors on the cell […]
The Influence of RNA Editing on miRNA Processing and Gene Regulation
Brent Shepherd and Dr. Evan Johnson, Statistics The emergence of high-throughput DNA sequencing within the past decade has redefined the world of molecular research. Mapping a human genome, a project that cost the United States government almost $3 billion and took 13 years to complete, is now speculated to soon be less than a week-long […]
Role of AMP Kinase in the Regulation of Cortisol Release From the Adrenal Gland
Dr. Allan M. Judd, Department of Physiology and Developmental Biology Evaluation of how well the scholarly objectives of the proposals were met Throughout the three years the funding of this proposal was utilized , I (Dr. Judd) have weekly laboratory meetings and journal clubs for undergraduate and graduate students in the laboratory. At the journal […]
T Cell Immunotherapy of Infection Disease and Cancer
Scott Weber, Microbiology and Molecular Biology 1) Project Summary This project was focused on improving the immune response to infectious disease and cancer. We have engineered T cell receptors with 1000-fold increase in affinity and will characterize their value as diagnostics and therapeutics. In addition, we examined changes in T cell function due to the […]
The Role of Nrf2 In Prevention of Oxidative Stress Caused by Valproic Acid
Madison Wilson and Jason M. Hansen, Physiology & Developmental Biology Introduction Valproic acid (VPA) is a common drug used to treat epileptic seizures as well as bipolar disease. Over the past decade, the use of these drugs has increased dramatically as they are now being prescribed as antipsychotics, mood stabilizers, and are currently being tested […]
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