Nalani Yamada and Professor Beverly Roeder DVM, PhD, Biology Department Dairy cows are bred and utilized to produce large quantities of milk daily and are held to high production standards. Greater production or manipulated production activity can affect the homeostasis state of an animal and lead to production-related metabolic diseases (PRMDs). In a previous study focused […]
Search Results for: disease
Validation of Genetic Association between Variants in PPP3R1 and MAPT and Rate of Progression of Alzheimer’s Disease
David Peterson and Dr. John S. K. Kauwe, Biology Introduction Alzheimer’s disease (AD) is the most common neurodegenerative disease, affecting more than 4.5 million people in the US. Genetic studies of AD have previously identified mutations in three genes (APP, PSEN1 and PSEN2) and polymorphism in APOE as risk factors. These findings have led to […]
Genetic Factors that Influence Tau Protein Levels in CSF and Risk for Alzheimer’s Disease
David Patty and Dr. John SK Kauwe, Biology Alzheimer’s Disease, the most common form of dementia, affects nearly 6 million Americans. Its effects on the individual range from mild impairment of memory to the complete destruction of the victim’s identity and their ability to perform everyday tasks. They become a heavy burden on their family, […]
Alzheimer’s Disease and Mitochondrial Genome Copy Number
Miles McKee and Dr. John Kauwe, Biology The purpose of this research project was to identify genetic variation, or more specifically variation in the average number of mitochondria per cell, and determine how these variations relate to risk for Alzheimer’s disease (AD). The project started off with a measurement of the ratio of mitochondrial genome […]
PAS Kinase: A Target for Metabolic Disease
Jordan Mackay and Dr. Julianne Grose, Molecular and Microbiology Many diseases that affect humankind are poorly understood. The medical and scientific communities alike rely heavily on basic scientific research to fuel dissemination of knowledge to said communities for further applied research, including clinical and pharmaceutical efforts. Diabetes is still poorly understood despite its prevalence in […]
Search for Genomic Factors that Influence Cerebrospinal Fluid Levels of YKL40, a Novel Biomarker for Alzheimer’s Disease
Mo Lee and Dr. John S.K. Kauwe, Biology Department Alzheimer’s disease is the most common form of dementia in the United States. It is a complex neurodegenerative disorder featured by gradual onset and progression of memory loss combined with deficits in executive functioning, language, visuospatial abilities, personality, behavior and self-care. There are basically two types […]
Proteomics Approach to Solving Alzheimer’s Disease
Ryan Egbert and Dr. John Kauwe, Biology Department Our project has gone according to plan, with a few small modifications along the way. Initially, we had proposed to incorporate gender profiling in attempt to understand the differences in serum proteomics profiles in men and women. Due to the difficulties in carrying out this aspect of […]
RAGE Expression in Inflammatory Lung Diseases Triggered by Air Pollutants
Tyler Earley and Dr. Paul Reynolds, Physiology and Developmental Biology I was given a research grant of $1,500. My project was centered around discovery of cellsignaling pathways linked to inflammation specific to the lung. We studied a receptor that may be shown to integrally participate in inflammation in such diseases as COPD and Asthma. My […]
Finding Novel Variants in APP, PS1 and PS2, that alter Gene Functionality and Lead to Familial Alzheimer’s Disease
Matthew Cable-Fabiszak and Dr. John Kauwe, Biology Department Review of Purpose of Project The planned objective of this mentored research opportunity was to identify families in the Cache County Aging Study that harbored mutations in three specific genes known to cause familial Alzheimer’s disease: APP, PS1, and PS2. This knowledge would have been beneficial because […]
Locating Resistance to The Tomato Virus Disease “Tomov” With RFLP Markers on Chromosome 6
Heidi Lynn Stevens-Robbins and Dr. Eric N. Jellan, Agronomy & Horticulture Tomato yellow leaf curl virus (TYLCV) and tomato mottle virus (ToMoV), are both geminiviruses, and are considered major limiting factors in the commercially grown tomato (Lycopersicon esculentum Mill.) in Florida and the Middle East (1). These viruses have been identified as reducing yields and/or […]
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