Josue David Gonzalez Murcia and John Kauwe, Biology Department Introduction Alzheimer’s disease is one of the top 10 causes of death in the world and the 6th leading cause of death in the United States, with 5.5 million people diagnosed with the disease. Alzheimer’s cannot be cured, prevented or slowed. Most research with Alzheimer’s disease […]
Search Results for: disease
Do Differently Managed Dairy Cows with Production-related Metabolic Diseases have Similar Protein and Fat Species in Colostrum and Milk?
Holly Martin and Dr. Beverly Roeder, Biology Introduction Production-related metabolic diseases (PRMDs) in dairy cows threaten the livelihood of the animals as well as the productivity and success of the dairy industry. Because dairy cows supply an important food source for humans, understanding, managing, and preventing these diseases protects this source. Management and prevention of […]
Genetic Basis for Rheumatic Heart Disease in High Risk Families in Western Samoa
Eleni Tukuafu and John S.K. Kauwe, Department of Biology Introduction Rheumatic heart disease (RHD) is the most common form of acquired cardiovascular disease among children worldwide and results in 233,000 deaths annually. Although genetic and environmental factors are known to contribute to RHD, not much is known about genes that increase susceptibility. RHD results from […]
Determining the spatial relationship between iron, tau protein, and amyloid beta within the subiculum as a means to better detect Alzheimer’s disease
Brandon Herrington and Jonathan Wisco, Department of Physiology and Developmental Biology Introduction As the 6th leading cause of death in the United States1, and because of the significant deterioration it causes in the quality of life of its victims, Alzheimer’s disease is an area where research to improve its early diagnosis is paramount to establishing […]
P300 Latency in Alzheimer’s Disease: A Meta-Analysis and Meta-Regression
David Payne Bennett and Dawson Hedges, Psychology Introduction Developing a biomarker for accurate assessment and detection of Alzheimer’s disease was the goal of our research. The P300 component of the event-‐related potential has been indicated to apparently change with the progression of Alzheimer’s disease. As measuring the P300 is non-‐invasive and relatively easy, we sought […]
BYU undergraduates execute a familial study of non-demented individuals in high-risk Alzheimer’s disease pedigrees
John S.k. Kauwe, Biology Project Justification and Overview Successful enrollment in and completion of graduate programs requires a constellation of skills. Students must be prepared to plan and execute experiments, present their findings both verbally and in manuscript form and interact effectively with senior scientists in the field of their choice. In this MEG I […]
The role of Wnt signaling in normal muscle development and disease
Jeffery Barrow, Physiology and Developmental Biology My laboratory studies the role of Wnt signaling in regulating important events during embryogenesis. In order to better understand the function of this pathway, we study mouse mutants that lack the Porcupine (Porcn) gene which encodes a protein that is required for the secretion of all Wnt molecules. Prior […]
Association of Rare Genetic Variants to the Development and Progression of Alzheimer’s Disease
Cameron Schmutz and Dr. Keoni Kauwe, Biology Department INTRODUCTION Alzheimer’s disease (AD) is a fatal neurodegenerative disorder and is the leading cause of dementia.1,3 It is the sixth leading cause of death in the United States and is the only one that has no adequate prevention or cure. AD is characterized by a progressive loss […]
Assessment of TREM2 rs75932628 Association with Alzheimer’s Disease in a Population-based Sample: The Cache County Study
Josue D. Gonzalez Murcia a,1, Cameron Schmutz a,1, Caitlin Munger a, Ammon Perkes a, Aaron Gustin a, Michael Peterson a, Mark T.W. Ebbert a,b, Maria C. Norton c,d, JoAnn T. Tschanz d, Ronald G. Munger e, Christopher D. Corcoran f, John S.K. Kauwe a Abstract Recent studies have identified the rs75932628 (R47H) variant in TREM2 […]
Histological Validation of Alzheimer’s Disease and Cerebrovascular Disease Imaging Biomarkers
Brigham Barzee, Brett Gardiner, and Dr. Jon Wisco, Department of Physiology and Development Biology Introduction The purpose of this study is to analyze spatial co-localizations between amyloid beta (Aβ), tau, and iron in postmortem brains of Alzheimer’s disease (AD) and cerebrovascular disease (CVD) patients. Iron is readily visible in T2* magnetic resonance images (MRI), and […]
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