Amanda Stevens and Dr. Kim O’Neill, Microbiology and Molecular Biology Over the past few years, cancer prevention has become a more important focus for research in the fight against cancer. Recent studies suggest that perhaps as much as 70-80 % of all cancers could be prevented by diet alone. Ellagic acid is a compound found […]
Search Results for: cancer
Selenium Moderation of Estrogen Receptor-Beta (ER-b) Activation: A Mechanism for Prostate Cancer Chemoprevention
Josie Johnson and Dr. Merrill J. Christensen, Nutrition, Dietetics, and Food Science Introduction Prostate cancer is the second leading cause of cancer death in men (1). Results from a prospective cancer prevention trial showed that Se supplementation reduced prostate cancer incidence by 63% (2). One molecular mechanism by which Se may protect against prostate cancer […]
Bioassays on Ethnobotanical Plants With Potential Activity Against E. coli, Staphlococcus aureus, Candida albicans, and Hela Cancer Cells
Ryan David Huish and Dr. Rex G. Cates, Integrative Biology During a three month period, ethnobotanical interviews were conducted to identify and collect plants traditionally used to treat skin and mouth infections. Plant parts (i.e. inner bark, young or mature leaves, fruit, etc.) specific to the native informants’ knowledge were collected and preserved in 100% […]
Cytotoxicity of Thirty-Six Moroccan Plants Against Four Cancer Cell Lines and 3T3 Cells
J. Aukai Riordan and Dr. Rex G. Cates, Integrative Biology It is not hard to believe that eighty percent of the populations of Asia, Africa, and Latin America rely principally on traditional medicine for their primary source of health care. However, many people do not realize that many of the best-selling pharmaceuticals in the Western […]
A Novel Approach to Assessing the Metastatic Potential of Cancer Cells
Nyall Robert London, Jr. and Dr. Kim O’Neill, Microbiology and Molecular Biology Cancer remains a major cause of death around the world today. A major problem with cancer is metastasis or the spread of cancerous cells from the tumor to a secondary location. This occurs when cancer cells break away from a primary tumor, invade […]
Loss of Scribble Tumor Suppressor in Human Cancers: Atypical hScrib Expression and Localization in Malignant Breast Cancer
Daniel G. Fuja and Dr. Kim L. O’Neill, Microbiology and Molecular Biology Drosophila Melanogaster has been used for years in basic developmental and genetic research, because of its short life cycle, low cost, and ease of handling. One beneficial consequence of this extensive research is an increased knowledge of human cancer progression. Multiple homologues have […]
The Effects of Allergies on Cancer
Robert E. Beck and Dr. Ray M. Merrill, Health Sciences There has been some research conducted on the relationship between allergies and cancer. The goal of our research was to be able to compile all information in the medical literature in order for the associations between allergies and specific cancer sites (i.e. breast, prostate. etc.) […]
Using the BYU Supercomputer to Simulate Analogs of the Anti-cancer Drug Geldanamycin
Joshua Proulx and Dr. Merritt Andrus, Department of Chemistry and Biochemistry For my project I simulated the binding of geldanamycin in the ATP binding site of Heat shock protein-90 to assist Merritt Andrus’s research in designing a better anti-cancer drug. Hsp-90 is a protein found in the cells of many organisms including humans. It functions […]
Optimization of Kidney Cancer Cell Assay Conditions
Bryce Harbertson and Dr. Heidi Vollmer-Snarr, Chemistry and Biochemistry Photodynamic therapy involves the use of light-sensitive compounds that, upon irradiation, become lethal to cells. These light-sensitive compounds are referred to as photosensitizers. A class of compounds known as pyridinium bis-retinoids are being investigated as potential photosensitizers, and therefore, chemotherapeutic drugs (Figure 1). One of the […]
Stromal-cell Derived Factor-1α and Macrophages Increased Invasive Potential of Breast Cancer Cells
Devin Twitchell and Dr. Kim L. O’Neill, Molecular Biology and Microbiology Research has demonstrated that in some tumors, up to fifty percent of a breast tumor’s mass is composed of macrophages (1). It is well recognized that macrophages can inhibit tumor growth and, paradoxically, stimulate tumor growth and metastasis depending on the proteins produced (2). […]
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