Greg Taylor and Jack Sites, Biology The focus of this project was 1) to determine sexual dimorphism in head and body structures in the lizard family Corytophanidae 2) analyze phylogenetic relationships between the species within the family, and 3) analyze the relationship with other lizard clades. Research started in October of 2014 with writing letters […]
Archives for February 2016
Experimental Testing of a Carbon Nanotube Lance Array for Nanoinjections
Dallin Lindstrom and Brian Jensen, Mechanical Engineering Introduction A silicon nanoinjection lance array has previously been developed to deliver charged propidium iodide (PI) molecules into tens of thousands of HeLa culture cells simultaneously. DNA is also charged, so applying a voltage to the lance array attracts DNA molecules to the lances. The voltage can be […]
Association of TM2D3 gene with lateonset of Alzheimer’s disease in Cache County
Eleni Tukuafu and Dr. John S. K. Kauwe, Biology Introduction It is estimated that 5.2 million Americans have Alzheimer’s disease. It is currently the 6th leading cause of death in America, killing around 500,000 seniors every year. A 68% increase of death from Alzheimer’s disease was observed from the year 2000 to 2010. These numbers […]
Alcohol and Nicotine co-Dependence
Taylor Woodward and Scott Steffensen, Psychology Introduction Addiction is a diabolical neurochemical trap that robs people of their agency and catastrophically affects virtually every aspect of an addict’s life. Alcohol is one of the most statistically widespread and harmful addictive substances in our society (Nutt, King et al. 2010). Through physiological means, it destroys an […]
Effect of Myostatin Pathway Inhibition on Fibroblast Activity Using a Novel Small Molecule
Seth Hampton and Dr. Robert Hyldahl, Exercise Science Introduction Fibroblasts play a key role in repairing injured tissue by secreting collagen and growth factors into the tissue. In states of disease and overuse, fibroblast activity can become overly abundant and can lead to skeletal muscle fibrosis, decreasing strength and muscle elasticity. This fibrotic condition can […]
Testing the Effect of Antioxidants on the pathogenesis of Alzheimer’s disease through the RAGE/NF-kB Inflammatory Pathway
Harrison Snyder and Jonathan Wisco, Physiology and Developmental Biology The Receptor for Advanced Glycation Endproducts (RAGE) is known to have a role in inflammatory processes. When produced in excess it induces oxidative stress by activating a number of ligand enzymes, resulting in the generation of excessive cytosolic reactive oxidant species. This oxidative stress then stimulates […]
The Role Of Palmitate in Upregulating Nr4a1 and Nr4a3 Proposal Status
Jordan Tingey and Jeffery Tessem, Nutrition, Dietetics, and Food Science This project focused on the effects of palmitate on transcription factors, Nr4a1 and Nr4a3. All experiments were preformed on a beta cell line. The first experiment was done to show if palmitate effected proliferation of Nr4a1 and Nr4a3 knockout cell lines. This experiment was preformed […]
Discovery and Characterization of Bacteriophage to control MRSA
Jacob B. Hatch and Bradford Berges, Microbiology and Molecular Biology Introduction About 20% of humans are carriers of Staphylococcus aureus (SA). There were an estimated 11,000 deaths in the United States in 2005 attributed to SA, with the majority caused by MRSA (Methicillin Resistant Staphylococcus Aureus) isolates [1]. Many MRSA isolates have developed resistance to […]
Ligament microstructure analysis
Michael Gillespie and Jonathan Wisco, Physiology and Developmental Biology Introduction Due to the relatively poor fiber contrast of tendons in comparison with muscles, the anatomical, and therefore, functional relationship of muscle attachments to bones via tendons has not been well mapped. We were interested in mapping the 3D gross anatomical structure of tendons using a […]
Targeting Superoxide Dismutase-1 in Cancer
Laura Oh and Josh Andersen, Department of Chemistry and Biochemistry Introduction SOD1 is overexpressed in many cancers such as lung adenocarcinoma, non- small-cell lung cancer, and 70% of primary breast cancers. Traditionally, SOD1 is known as an antioxidant in the human body, but only 1% of SOD1 expressed in cells is necessary to keep superoxide […]
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