The Effects of Selenium, Resveratrol, and a Resveratrol Derivative on Human Prostate Cancer LNCaP and 22Rv1 Cell Lines

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Jason Morris and Dr. Merrill J. Christensen – Nutrition, Dietetics, and Food Sciences The goal of this project was to determine whether there was a synergistic anticarcinogenic effect between selenium and resveratrol, both of which had independently demonstrated the ability to inhibit prostate cancer cell proliferation. Additionally, the project also sought to determine whether a […]

Effect of High Fat Diet With AICAR Treatment on Mitochondrial Biogenesis of Male Rats

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David Mills and Professor Chad Hancock, Nutrition, Dietetics, and Food Science The original goal for my project was to study how a high-fat diet affects insulin resistance in slow twitch and fast twitch muscle fibers in rats. We hypothesized that administering a drug named acipamox, which lowers cellular free fatty acid levels, would restore insulin […]

Selenium-Regulation of Steroid Hormone-Mediated Gene Expression in Transformed Human Prostate Epithelial Cells

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David R. Nielsen and Dr. Merril Christensen, Food and Science and Nutrition Introduction Prostate cancer is the second leading cause of cancer-related deaths in American men, with current estimates projecting 179,300 new cases and 37,000 deaths this year [1]. The development of prostate cancer may be divided into three stages: initiation, promotion, and progression. During […]

The Molecular Basis for Prostate Cancer Risk Reduction by Selenium

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Josie Johnson and Dr. Merril J. Christensen, Food Science and Nutrition Prostate cancer is the most common form of cancer and the leading cause of cancer death in American men.1 Results from a cancer prevention trial performed by Clark et.al.2 show that selenium (Se) supplementation in male subjects reduced cancer incidence by 75%. The molecular […]

Bone Density in College Women: The First Phase of a Two Phase Study of the Early, Modifiable Markers of Osteoporosis and the Effect of Calcium and Magnesium Supplements

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Jason Boyd and Dr. Bruce H. Woolley, Food Science and Nutrition Introduction Peak bone mass of pre-menopausal women has been established as a major risk factor for postmenopausal osteoporosis and related bone fractures (4). Previous research evidence suggest that bone mass of both the peripheral and axial skeleton is stable for women before menopause (1,2). […]

Final Report to the ORCA Scholarship Committee

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Serena Arave, Shenai Fisher, Lori MacArthur, Cary Rogers and Dr. Diana McGuire, Food Science and Nutrition Summary In conjunction with LDS Welfare Services and the Brigham Young University Food Science and Nutrition Department the International Food Relief Committee met the project objective to develop food box prototypes that are culturally and nutritionally appropriate for global […]

Does Selenium Alter the Expression of the Large T Antigen in TRAMP Mice?

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Britlyn Orgill and Dr. Merrill Christensen, Department of Nutrition, Dietetics, & Food Science Main Text Prostate cancer is the second most common cancer in American men. The American Cancer Society predicts that 217,730 cases of prostate cancer will be diagnosed and that 32,050 men will die from the disease in the year 2010 (1). Since […]

Orange Phenolic Compound Consumption Increases Serum Antioxidant Capacity Independent of Orange Sugar and Ascorbic Acid

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Kfir Orgad and Dr. Tory Parker, Nutrition Department Main Text Recent scientific data has proposed that the oxidation of low density lipoproteins is the leading cause of cardiovascular disease, and thus premature death, in America. These studies have shown that people who consume more fruits and vegetables are less likely to develop cardiovascular disease as […]

Potential Synergism between Antioxidants found in Blueberries (Vaccinium Cyanococcus)

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Richard Low and Dr. Tory Parker, Department of Nutrition, Dietetics, and Food Science Main Text According to a review by Battino et al. (2009), blueberry consumption can regulate blood pressure, inhibit cancer growth, and improve cardiovascular health by preventing plaque buildup in the arteries. Naturally occurring antioxidants found in fruits and vegetables that are thought […]