Paul Reynolds, Physiology and Developmental Biology Academic Objectives Met and Results Observed Funding available through this MEG award has provided an opportunity for me to meet many academic objectives I’ve determined to be important in the early stages of my faculty appointment at BYU. First of all, I have been able to move my on […]
The role of Wnt signaling in normal muscle development and disease
Jeffery Barrow, Physiology and Developmental Biology My laboratory studies the role of Wnt signaling in regulating important events during embryogenesis. In order to better understand the function of this pathway, we study mouse mutants that lack the Porcupine (Porcn) gene which encodes a protein that is required for the secretion of all Wnt molecules. Prior […]
Cloning The Ultrabithorax Gene In Tribolium Castaneum
Kara I. Ludlow and Dr. Randy Bennett, Zoology My original proposal was to clone the extradenticle gene in Tribolium castaneum (red flour beetle); however, I worked in conjunction with Laura Newell who received an ORCA grant to work with Dr. Bennett cloning the Ultrabithorax gene of the red flour beetle. To further previous research, it […]
ROLE OF PRIMARY CILIA IN OSTEOARTHRITIS
David Kooyman Mentoring in my lab in 2012 has led to both tangible and intangible results. The tangible results for this year include two posters presented at an international meeting by undergraduate students, ORCA grants received by two students, international recognition by a team of undergraduate students, two papers published, three papers in preparation to […]
MEG Final Report
Jeff Edwards and John Smith I) Evaluation of academic objectives of the proposal The objectives of this award were met, especially in regard to the mentoring focus of the award. The students have been mentored and trained in an effective manner as outlined in my Mentoring Plan (see below). This includes mentoring students in research, […]
AMPK Activation in Aged Skeletal Muscle After Muscle Contraction
David M Thomson, Physiology and Developmental Biology Evaluation of academic objectives and project findings The purpose of this mentoring environment grant was to determine the effect of aging on skeletal muscle AMPK intracellular localization and activation by muscle contraction. Funding for the project is now completed. The primary research objectives and findings are listed below: […]
Regulation of the Transcription Factor CREB in Skeletal Muscle after Exercise
David M Thomson, Physiology and Developmental Biology Evaluation of mentoring environment My laboratory is running quite smoothly now. The students in the laboratory are proficient in performing experiments, obtaining data and interpreting it. My first undergraduate students have recently graduated, and I now have a nice array of experienced and newer inexperienced students, so the […]
The Role of PAS-kinase In Skeletal Muscle Hypertrophy and Endurance Adaptation
Dr. David Thomson, Department of Physiology & Developmental Biology Evaluation of academic objectives and project findings The purpose of this mentoring environment grant was to determine whether the presence of the protein PAS-kinase (PASK) affects muscle growth and/or endurance performance. Our primary model system was the PASK knockout mouse (PASK-KO) and findings from this mouse […]
Secretory phospholipase A2
Dr. John Bell, Department of Physiology & Developmental Biology Abstract of original proposal Secretory phospholipase A2 (sPLA2) binds to and hydrolyzes cell membranes. It is important in inflammatory responses and diseases including septic shock, atherosclerosis, and cancer. Normally, cells resist the enzyme’s action, but they become susceptible early during the process of either biochemically-programmed or […]
Endocannabinoid Enzyme Expression in the Hippocampus
Dr. Jeff Edwards, Department of Physiology & Developmental Biology Evaluation of academic objectives of the proposal The objectives of this award were met, especially in regard to the mentoring focus of the award. The students have been mentored and trained in an effective manner as outlined below. Using this mentoring environment and the experiences gained […]