David Kooyman

Mentoring in my lab in 2012 has led to both tangible and intangible results. The tangible results for this year include two posters presented at an international meeting by undergraduate students, ORCA grants received by two students, international recognition by a team of undergraduate students, two papers published, three papers in preparation to be submitted within 30 days. The intangible results come as students return from interviews to medical and dental schools with stories of how confident they felt talking about their research. They also come in the form of the excitement I see in students when they talk about their work at our weekly lab meetings. The tangible details are as follows:

Student Co‐Authored Peer‐Reviewed Manuscripts (undergraduates underlined) published in 2012:

1. D.W. Holt, M.L. Henderson, C.E. Stockdale, J.T. Farrell, D.L. Kooyman, L.C. Bridgewater, R.E. Seegmiller. 2012. Osteoarthritis‐like changes in the heterozygous sedc mouse associated with the HtrA1‐ Ddr2‐Mmp‐13 degradative pathway: a new model of osteoarthritis. Osteo and Cart. 2012 20(5):430‐9. (Direct result of the 2011/12 MEG)

2. K.W. Airmet, J.D. Hinckley, L.T. Tree, M. Moss, S. Blumell, K. Ulicny, A.K. Gustafson, M. Weed, R. Theodosis, M. Lehnardt, J. Genho, M.R. Stevens and D.L. Kooyman. 2012. Construction of a Llama Bacterial Artificial Chromosome Library with Approximately 9‐fold Genome Equivalent Coverage. J Biomed and Biotech. Volume 2012, Article ID 371414, 4 pages. (Indirect result of the 2011/12 MEG. The MEG freed up valuable resources that allowed us to complete this project and get it published.)

Student Co‐Authored Peer‐Reviewed Manuscripts (undergraduates underlined) submission imminent:

1. Establishing Homozygous Sponlyoepiphyseal Dysplasia Congenita as a Model of Osteoarthritis. Macdonald, D.W, Farrell, J., Heimann, N., Holt, D.W., Kooyman, D.L.*, Seegmiller, R.E. Journal of histochemistry and cytochemistry. Ready to submit on October 31st. (Direct result of the 2011/12 MEG)

2. Osteoarthritis in The Temporomandibular Joint of Col2a1 Mutant Mice. M. L. Ricks, J.T. Farrell, D. J. Falk, D W. Holt, M. Rees, J. Carr, T. Williams, B.A. Nichols , L. C. Bridgewater, P.R. Reynolds, D. L. Kooyman†, and R. E. Seegmiller. Archives of Oral Biology Ready to submit on October 31st. (Direct result of the 2011/12 MEG)

3. D.M. Peterson, D. Weipert, K.W. Airmet, S. Killingsworth, M.R. Klein, T.D. Beardsley, D.W. Macdonald, L.C. Bridgewater, R.E. Seegmiller, D.L. Kooyman. Premature osteoarthritis in the Temporomandibular and Knee Joints of Bardet‐Biedle Syndrome Mice. Targeted for Osteoarthritis and Cartilage in November. (Direct result of the 2011/12 MEG)

Student Poster Presentations and Venues (undergraduates underlined):

1. Kartchner, J.Z., D.M. Peterson, D.J. Larkin, A.S. Doxey, W.R. Hollis, J.L. Rees, C. Ingersoll, G.G. Jackson, S.K. Wilhelm, S.S. Haynie, R.E. Seegmiller, P.R. Reynolds and D.L. Kooyman. 2012 The temporal expression of biomarkers associated with osteoarthritis after knee destabilizing surgery in mice with and without Receptor for Advanced Glycation End Products (RAGE). Experimental Biology LB 139 (Direct result of the 2011/12 MEG)

2. Ricks, M.L., D.J. Falk, J. Farrell, M.B. Rees, J.M. Carr, D.T. Williams, L.C. Bridgewater, D.L. Kooyman and R.E. Seegmiller. 2012 Premature osteoarthritis in the temporomandibular joint of heterozygous disproportionate micromelia mice. Experimental Biology LB 118 (Direct result of the 2011/12 MEG)