Matthew Woll and Dr. Noel Owen, Chemistry and Biochemistry Many important and useful biological compounds are found in plants. Extensive work has been done on evaluating anti-cancer 1, 2, anti-malarial 3, and anti-viral 4 properties of plants. The Yaqui Indians of northern Mexico have traditionally used many natural products to cure various diseases. Gloria Moroyoqui, […]
Thermodynamic Studies of Technologically Significant Silicides
Rebecca Stevens and Dr. Juliana Boerio-Goates, Chemistry and Biochemistry Vanadium, molybdenum, and tungsten silicides are inorganic materials that have many practical applications at high temperatures and high pressures1. Eight compounds which are of particular interest are found in Table 1. Accurate thermodynamic data aids in the synthesis of high purity, single phase materials. For example, […]
Synthesis Of Bioconjugate Dimers Used To Probe The Structure Of PGlycoprotein
Emily Parker and Dr. Merritt B. Andrus, Chemistry and Biochemistry Chemotherapy is one of the primary treatments for cancer today. A patient’s life may depend on its efficacy, so when he or she develops multi-drug resistance (MDR) the results can be devastating. MDR, a clinical condition manifested by the failure of chemotherapy, is primarily due […]
Cyclooxygenase 1 and 2: Development of Canine InVitro and Whole Blood Assays for Non-Steroidal Anti-inflammatory Drugs
Nicole L. Hatch and Dr. Daniel L. Simmons, Chemistry and Biochemistry Non-steroidal anti-inflammatory drugs (NSAIDS) are the basis for a multi-billion dollar pharmaceutical market. Their target, Cyclooxygenase (COX), might from an economic standpoint be considered the most important enzyme known to man (1). NSAIDS inhibit COX from producing arachdonic acid, a precursor to prostaglandins (2). […]
Photodynamic Therapy as a Cure for ICK
Spencer C. Davis and Dr. James Thorne, Chemistry Photodynamic Therapy (PDT) is a new technique currently used to treat malignant cancer tumors in humans. This treatment uses the principles of light in a manner similar to types of radiation therapy. In PDT a photosensitizing dye is injected intraveneously diffusing to all cells. Tumor cell absorption […]
The Process Of Creating Microsolvated Ions Using Electrospray Ionization And Fourier-Transform Ion Cycoltron Resonance Mass Spectrometry
Laura Cunningham and Dr. David V. Dearden, Chemistry and Biochemistry Microsolvation is the process of attaching solvent molecules to a host molecule in the gas phase, creating a system which exhibits characteristics between that of gas-phase and solution-phase systems. Study of these microsolvated systems can help us to understand the difference between gas-phase and solution-phase […]
Na+/K+ ATPase Concentrations In Pregnancy-Related Tissues
Sarah M. Buck and Dr. Steven Graves, Chemistry and Biochemistry Na+/K+ ATPase, or sodium pump, is an integral protein that is essential in maintaining proper intracellular concentrations of Na+ and K+. The sodium pump exists in three isoforms which are present in varying numbers and relative distribution in different tissues. As the pump moves the […]
An Efficient Reductive Amination Protocol Using Benzylamine-Borane As Reducing Agent
Adam M. Bowman and Dr. Matt A. Peterson, Chemistry and Biochemistry Reductive amination is an important method used to generate amines from aldehydes or ketones. This process occurs in a two-step in situ reaction. First, an iminium intermediate is formed when the carbonyl compound condenses with ammonia or a primary or secondary amine. This intermediate […]
CREATION OF MUTATIONS OF THE HUMAN CDC34 GENE: A REGULATOR OF THE CELL DIVISION CYCLE
Craig Rogers, Department of Chemistry and Biochemistry Abstract In the yeast strain Saccharomyces cerevlslae, the gene CDC34 encodes for a ubiquitln ligase necessary for the transition from GI to the S phase of the cell division cycle. CDC34 is one of several cell division cycle (CDC) genes that act as checkpoints, or regulators, of the […]
A STUDY OF RANDOM AMPLIFIED POlYMORPHIC DNA (RAPD) AS MARKERS IN A liNKAGE MAP OF PEROMVSCUS USING TWO INBRED STRAINS
Dan Ririe, Department of Chemistry Introduction Within the mouse genus Peromyscus there exists many pericentric inversions containing linkage groups, genes which do not recombine. It has been hypothesized that genes inherited together provide the selective pressure which has caused speciation within the genus. The purpose of this project was to aid ongoing research in the […]
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