Sara Pratt and Dr. Daniel Austin, Department of Chemistry and Biochemistry In this project we wanted to see if bacteria can survive a process called electrospray ionization (ESI). While bacteria survival of ESI has not previously been demonstrated, viruses survivability has1. The process of ESI consists of spraying a solution of the desired analyte in […]
Bioactive Lipid Analysis of Asthma-Induced Lung Tissue with a Focus on Biomarker Identification
Mackay Merrill and Dr. John Prince, Department of Chemistry and Biochemistry Overview Initially, the goal of my project was to search for biologically active lipids in the lung tissue of mice with and without asthma (as opposed to those which simply form the membranes of cells) and determine if any of these lipids could serve […]
Follicular Dendritic Cells and Activation of T Cells Bearing Latent HIV
Jared Huber and Dr. Gregory F. Burton GOAL Determine the pathway by which FDC cytokines activate HIV transcription in CD4+ T‐cells harboring latent HIV. BACKGROUND & IMPORTANCE HIV Latency in CD4+ T Cells Human Immunodeficiency Virus (HIV) attacks the immune system by infecting helper (CD4+) T‐cells. HIV injects viral genetic material into the T‐cell, and […]
Synthesis of S-Equol using Heck Coupling Reaction and Phase-Transfer Catalysis
Chelsey Hancock Please list all accomplishments, achievements, publications, presentations, or other scholarly productivity that resulted from your ORCA project. This may include submissions to peer-reviewed journals, conference presentations or papers, performances, exhibitions, internships, scholarships, graduate school opportunities, local presentations, or awards that followed your mentoring experience. Through this ORCA grant, I was able to present […]
Reactivation of latent HIV in CD4+ T cells through FDC costimulation
Matthew Greer and Dr. Greg Burton, Department of Chemistry and Biochemistry I received an ORCA grant for a project entitled “Reactivation of latent HIV in CD4+ T cells through FDC costimulation.” The original hypothesis of this research was that the factor FDCs (follicular dendritic cells) produce to reactivate latent HIV in T cells is a […]
Genetic Rescue of the Irk 2 Knockout Phenotype by Ectopic Expression of Irk 2 WT
Brandon Gassaway and Dr. Emily Bates, Department of Chemistry and Biochemistry Anderson-Tawil Syndrome (ATS) is characterized by morphological defects including clinodactyly (abnormal curvature of digits), syndactyly (fused digits), micrognathia (small jaw), cleft palate, and hypertelorism (wide-set eyes) as well as periodic paralysis and heart arrhythmia. Mutations in inwardly rectifying potassium (Irk) channels are found in […]
Analysis of the Kinetics of Atmospherically Important Reactions
Marie Killian (Chilton) and Dr. Jaron Hansen, Department of Chemistry and Biochemistry Organic peroxy radicals react to form tropospheric ozone, which harms the health of humans and vegetation and is considered the most significant pollutant in rural areas.1 Many of the individual reactions in the overall mechanism for ozone formation involve radicals. Radicals are highly […]
The Total Synthesis of S-equol Using Phase Transfer Catalysis
Eric Bready and Dr. Merritt Andrus, Department of Chemistry and Biochemistry The purpose of this project was completion of the total organic synthesis of the anti-cancer compound (S)-equol. My goal was to carry out our planned synthesis of this molecule using Phase Transfer Catalysts, (PTCs), which promote the formation of the S enantiomer as opposed […]
In vitro Activation of Human Follicular Dentritic Cells and its Effects on Human Immunodeficiency Virus Infection
Sean Llewellyn and Dr. Gregory F. Burton, Department of Chemistry and Biochemistry Importance of Project HIV is known to survive on follicular dendritic cells (FDCs) for many months and is believed to contribute to persisting HIV infection. FDCs protect HIV from degradation, thereby prolonging the infectivity of the virus. Moreover, when virus is trapped on […]
Multivariate Factor Analysis of a Rocky Mountain Lichen Set
S. Aaron Ross and Dr. Nolan F. Mangelson, Chemistry and Biochemistry Lichens are a symbiotic relationship between a fungus and an alga. They have no root system, so although they grow off rocks and trees, they need to gather their nutrients from the air. Their great dependence on the atmosphere makes them very susceptible to […]
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