Nicole L. Hatch and Dr. Daniel L. Simmons, Chemistry and Biochemistry Non-steroidal anti-inflammatory drugs (NSAIDS) are the basis for a multi-billion dollar pharmaceutical market. Their target, Cyclooxygenase (COX), might from an economic standpoint be considered the most important enzyme known to man.1 COX is the key enzyme in the transformation of arachidonic acid into prostaglandins, […]
Can Achiral Hosts Perform Chiral Induction?
Eric S. Handberg and Dr. David V. Dearden, Chemistry and Biochemistry Introduction Host exchange experiments (see Figure 1) compare the fit of left-handed molecules (L-) and right-handed molecules (D-) in a host. Molecules that possess this “handedness” property are said to be chiral. In chiral crown ether host exchange experiments, chiral crown ethers distinguish the […]
Automatic Sensor and Action Selection
Charles Parkinson Fry and Professor Todd Peterson, Computer Science Continuous state spaces can be quite useful in Q-learning. Many real world problems are simply not discrete. An attempt to represent continuous values using a discrete state space is inherently problematic, as the selected level of discritization will likely be imperfect and unable to adapt to […]
Cytotoxic Activity of Euphorbia Polycarpa
Larry C. Ford and Drs. Noel L. Owen, Chemistry and Biochemistry and Steven G. Wood, Chemistry and Biochemistry With antimicrobial resistance on the rise, research is turning more and more to natural sources for medicinal products (the original source, ironically, for most known antimicrobials). Under the aegis of the Natural Product Center here on campus, […]
Induction of a Novel Form of Cyclooxygenase by Non-Steroidal Anti-inflammatory Drugs
Nathan K. Evanson and Dr. Daniel L. Simmons, Chemistry and Biochemistry For many years, non-steroidal anti-inflammatory drugs (NSAIDs) have been used to treat pain, fever, and inflammation. The analgesic, antipyretic, and anti-inflammatory effects of these drugs have been attributed to the ability of these drugs to inhibit the activity of cyclooxygenase (COX) enzymes1. COX enzymes […]
Rapid Capillary Electrophoresis Assay for the Isoenzyme, TK1, as an Indicator for Breast Cancer
Mari Evans and Dr. Milton L. Lee, Chemistry and Biochemistry The isoenzyme thymidine kinase (TK1), found in human serum, has been shown to be a cancer tumor marker. It has demonstrated both diagnostic and prognostic value in the treatment of breast cancer.1 Currently TK1 levels are measured by radioimmunoassay and enzyme-linked immunosorbant assay (ELISA). Radioimmunoassay […]
The Quantum Mechanical Probability Current for Nonrelativistic Particles with Spin
Philip Du Toit and Dr. Jean Francois Van Huele Introduction Quantum mechanics attributes to matter the properties of waves. The postulate that matter behaves as a wave and can be described by a wave function provides a mathematical description or model of many previously unexplained physical phenomena such as the diffraction pattern of an electron […]
Calorimitry Data Tracking the Encapsulation of Small Organic Water Contaminants by Cavitand [Co412]-8
Julie K. Cope and Dr. Roger G. Harrison, Chemistry Cavitand [Co412]-8 is a cage-like molecule having an inner cavity with a volume of approximately 1375 Å that traps small organic molecules. The “1” in the chemical formula represents resorc[4]arene, a bowl-shaped molecule1. Two resorc[4]arenes are connected with four cobalt molecules to form the cavitand [Co412]-8. […]
Phosphate and Ferritin Iron Deposition Kinetics
David D. Brosnahan and Dr. Gerald D. Watt, Chemistry and Biochemistry I performed a ferritin iron reconstitution experiment, making 10 sequential additions of 10 ferrous ions per ferritin molecule at 10- minute intervals (see Figure 1). Monitoring the reaction at 375 nm, I observed a fast initial absorbance change representing iron oxidation. After the initial […]
Regulation of G-Protein Signaling by Phosducin-Like Protein
Steven M. Bray and Professor Steven M. Bray, Chemistry and Biochemistry Introduction and Project Aim G-protein signaling is one of the major pathways which cells utilize to transmit messages. The signaling pathway consists of a receptor coupled to a G-protein, which activates secondary messengers. Signaling molecules, such as hormones and neurotransmitters, bind receptors on the cell […]
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