Dr. John Bell, Department of Physiology & Developmental Biology Abstract of original proposal Secretory phospholipase A2 (sPLA2) binds to and hydrolyzes cell membranes. It is important in inflammatory responses and diseases including septic shock, atherosclerosis, and cancer. Normally, cells resist the enzyme’s action, but they become susceptible early during the process of either biochemically-programmed or […]
Search Results for: human
A Comparative History of Nordic Literary Cultures
Dr. Steven Sondrup, Department of Humanities, Classics, and Comparative Literature I received a MEG in December of 2009 and, thus, pursued the goals outlined in that application during 2010 and am continuing through 2011. The proposal was to have selected students work closely with me on preparing a manuscript on the comparative history of Nordic […]
Development of Real-Time Polymerase Chain Reaction (q-PCR) Assays for the Specific Detection and Characterization of Select Bacterial Pathogens
Dr. Richard Robison, Department of Microbiology & Molecular Biology The Specific aims for the project were as follows Develop q-PCR reactions for specific target genes of bacterial pathogens Primer generation software will be used to design primer and probe sequences that will theoretically perform optimally in PCR reactions. All sequences will be subjected to BLAST […]
Cytokine Signaling in the Microenvironment May Aid in Tumor Development and Progression
Dr. Kim O’Neill, Department of Microbiology and Molecular Biology Studies have indicated that in breast tumors a high number of tumor associated macrophages (TAM’s) is indicative of a poor prognosis. TAM’s in the breast tumor microenvironment generally have a compromised immune response and focus their energy toward tissue repair which leads to angiogenesis, tumor growth, […]
A Randomized-Controlled Trial of the Effects of Resistance Training on Body Composition, Strength, Physical Activity, and Body Satisfaction in Postpartum Women
Dr. James LeCheminant, Department of Exercise Sciences Evaluation of how well the academic objectives of the proposal were met The purpose of this study, as submitted to the IRB, was to determine the effects of flexibility or resistance training on body composition, strength, spontaneous physical activity, cardiovascular disease risk factors, bone density, and body satisfaction, […]
BYU Students identify Genetic Factors that Modulate Cerebrospinal Fluid Protein Levels and Influence Risk for Alzheimer’s Disease
Dr. John Kauwe, Department of Biology Project Justification and Overview Successful enrollment in and completion of graduate programs requires a constellation of skills. Students must be prepared to plan and execute experiments, present their findings both verbally and in manuscript form and interact effectively with senior scientists in the field of their choice. In this […]
Supramolecular Chemistry for Students
Drs. Roger Harrison, John Lamb, David Dearden, Department of Chemistry & Biochemistry Evaluation of how well the academic objectives of the proposal were met Students working in the mentoring environment synthesized compounds and worked with separation and mass analyzer instruments. They learned how to make new compounds by organic synthesis and characterize their compounds by […]
International Center for Law and Religion Studies
Professor Cole Durham, J. Reuben Clark Law School Last year, Professor Cole Durham received a grant in the amount of $20,000 to help offset the cost of mentoring and training selected law students following their first year of law school. These funds were received and accounted for by the International Center for Law and Religion […]
Down Syndrome Pathway Analysis
Dr. Mark Clement, Department of Computer Science Many of the most serious medical problems that plague humanity are caused by problems in the genetic regulatory network. Heart disease, cancer and many other maladies could be cured if we understood how genes interact with each other in order to produce different symptoms. Many of these problems […]
Changes in Membrane Physical Properties during Chemotherapy
Dr. John Bell, Department of Physiology & Developmental Biology Abstract of original proposal Many chemotherapeutic agents treat cancer by inducing programmed cell death (apoptosis) in the tumor. One of the consequences of apoptosis is changes in the physical properties of the cell membrane. Some of these changes are important for other phagocytic cells to recognize […]