Harrison Snyder and Jonathan Wisco, Physiology and Developmental Biology The Receptor for Advanced Glycation Endproducts (RAGE) is known to have a role in inflammatory processes. When produced in excess it induces oxidative stress by activating a number of ligand enzymes, resulting in the generation of excessive cytosolic reactive oxidant species. This oxidative stress then stimulates […]
Search Results for: disease
Analysis of HMGCR as a Genetic Modifier for Alzheimer’s Disease
Brian Davis and Dr. John S.K. Kauwe, Biology Introduction Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that occurs predominantly later in life and represents the fourth most common cause of death in the developed world. Given the absence of curative treatment, discovering the factors related to the development of AD and the conversion from […]
Association of Rare Genetics Variants to the Protection of Alzheimer’s Disease in the Cache County Data Set
Josue David Gonzalez Murcia and John Kauwe, Biology Department Introduction Alzheimer’s disease is one of the top 10 causes of death in the world and the 6th leading cause of death in the United States, with 5.5 million people diagnosed with the disease. Alzheimer’s cannot be cured, prevented or slowed. Most research with Alzheimer’s disease […]
Confirming the spatial relationship between iron, tau protein, and amyloid beta within the subiculum as a means to better detect Alzheimer’s disease with Magnetic Resonance Imaging
Brandon Herrington and Jonathan Wisco, Department of Physiology and Developmental Biology Introduction As the 6th leading cause of death in the United States1, and because of the significant deterioration it causes in the quality of life of its victims, Alzheimer’s disease is an area where research to improve its early diagnosis is paramount to establishing […]
Presenilin E318G Variant and Alzheimer’s Disease Risk: The Cache Country Study
Ariel Hippen and John Kauwe, Biology Alzheimer’s disease is the leading cause of dementia in the elderly and the third most common cause of death in the United States. A vast number of genes regulate Alzheimer’s disease, including Presenilin 1 (PSEN1). It is possible that novel variants in the PSEN1 gene have an effect on […]
Discovery and confirmation of novel serum biomarkers diagnosing Alzheimer’s disease
Tyler Mower and Dr. John Kauwe, Department of Biology Dipti Jigar Shah1, Frederick Rohlfing2, Swati Anand1, W. Evan Johnson3, MeiHwa Tanielle Bench Alvarez1, Jesse Cobell2, Jackson King2, Sydney A. Young1, John S. K. Kauwe2, Steven W. Graves1,* 1Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 2Department of Biology, Brigham Young University, Provo, UT, […]
Iron as a Biomarker for Alzheimer’s Disease
Samuel Barlow and Dr. Jonathan Wisco, Physiology and Developmental Biology Introduction Alzheimer’s Disease (AD) is one of the highest causes of death in the United States. After the age of 65, the chance of getting Alzheimer’s doubles every five years. As the average lifespan of Americans increases, the importance of understanding AD and finding more […]
Replication of Gene-Gene Interactions in Large Alzheimer Disease Dataset
Kevin Boehme and Dr. John “Keoni” Kauwe, Biology Introduction Alzheimer’s disease (AD) is a common and complex neurodegenerative disease. It is the most common cause of dementia and is characterized by the accumulation of amyloid plaques and neurofibrillary tangles. To date, many genetic loci have been found that modify AD risk, but collectively, they explain […]
Importance of Rare Genetic Variants in Alzheimer’s Disease (TTC3)
Devan Bursey and Dr. John S.K. Kauwe, Department of Biology Introduction Alzheimer’s is a neurodegenerative disease caused by the formation of amyloid plaques and neurofibrillary tangles. Most current research on Alzheimer’s disease has focused on using genome-wide association studies to identify common genetic variants however; past research has shown that rare genetic variants play an […]
Customizing 3D models from MRI data: Creating educational anatomy models of neurologic disease
Brett Gardiner and Dr. Jon Wisco, Department of Physiology and Developmental Biology Introduction Neuroanatomy lab specimens are limited to cadaver availability and inconsistently demonstrate variations confronted in pathology. Using rapid prototyping (RP) technology to create 3D models from segmented MRI data offers distinct benefits to medical education. An efficient and replicable procedure for customizing these […]
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