Jesse Rowley and Dr. Gregory Burton, Microbiology Human Immunodeficiency Virus (HIV), the cause of AIDS, has eluded successful treatment since its discovery in the early 1980s. HIV is a retrovirus that infects and eventually destroys CD4+ T cells. In HIV infected individuals it is believed that during the longest phase of infection (latency) most viral […]
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Selenium Regulation of NF-κB Binding in Cancerous Human Prostate Epithelial Cells
Wayne K. Nelson and Dr. Merrill Christensen, Food Science and Nutrition According to the National Cancer Institute, prostate cancer is the most frequently diagnosed nonskin cancer in men. In 1997 alone, it is estimated that 209,900 men were diagnosed as having the disease. Prostate cancer is also the second leading cause of cancer related death […]
Follicular Dentritic Cells and Retention of HIV Quasi-Species
Candace McNaughton and Dr. Gregory Burton, Microbiology HIV infects millions of people worldwide; in the year 2000 alone, more than 3 million people died from AIDS (Acquired Immunodeficiency Syndrome) as a result of HIV infection1. In countries, such as the United States, where effective treatment is affordable, highly active antiretroiviral therapy (HAART) can reduce viral […]
Follicular Dendritic Cells (FDCs) and Sparing of CD4+ T cells from HIV/CD62L Triggered Apoptosis
Devon C. Cole and Dr. Greg Burton, Microbiology Both B and T lymphocytes intimately interact with follicular dendritic cells (FDCs) in lymphoid follicles of secondary lymphoid tissue (e.g., spleen, lymph node, and tonsils). FDCs trap and retain antigens needed to induce and maintain potent memory antibody responses. FDCs contribute both antigen dependent and independent signals […]
Production of Cytokines Interleukin-6 and Tumor Necrosis Factor Alpha in Human Adrenocortical H295R Cells
Joseph Johnson and Dr. Allan M. Judd, Zoology Difficulties associated with research into the physiology of the human adrenal gland have been alleviated due to the isolation of the human adrenocortical tumor cell-line, NCI-H295R, which retains the ability to produce adrenocortical steroids (e.g. aldosterone, cortisol, DHEA) when grown in culture (1). We investigated whether these […]
Fc Receptors in HIV Trapping and Retention on Follicular Dendritic Cells
Daniel Willis and Dr. Gregory Burton, Microbiology The development of HighlyActive Antiretroviral Therapy (HAART) against the HIV virus created a temporary excitement regarding a possible cure for HIV. This optimism resulted due to the fact that HAART blocked active HIV replication and reduced the level of HIV in the bloodstream to below standard limits of […]
Selenium Alters NF- B-Regulated Gene Expression in Human Prostate Cancer Cells
Aimee L Taylor and Dr. Merrill J Christensen, Nutrition, Dietetics and Food Science Introduction The American Cancer Society estimates that prostate cancer will account for 30% of new cancers in men, totaling over 189,000 new cases, with 30,200 deaths in 2002 (1). Because of its high prevalence and long latency time prostate cancer is an […]
Antigenotoxic Effects of Diallyl Disulfide and Allyl Disulfide on Benzo (a) pyrene induced DNA Damage in HepG2 Cells as measured by the Single Cell Gel Electrophoresis Assay
Corey W Speers and Dr. Kim L O’Neill, Microbiology Abstract One of the most effective strategies in cancer control is chemoprevention. Previous studies have shown naturally occurring organosulfur compounds from garlic and onion to be effective against carcinogenesis. The effects of two of these organosulfur compounds, diallyl sulfide (DAS) and diallyl disulfide (DADS), are thought […]
Reduction in Toxicity of Doxorubicin by á-Tocopherol Succinate (vitamin E) and Ascorbic Acid (vitamin C) in Human Adenocarcinoma Cells
Christie Michaud and Dr. Byron Murray, Microbiology Colorectal cancer is the second leading cause of cancer deaths in the United States and doxorubicin, is one of the more widely chemotherapeutic treatments for this disease. This study investigated the possibility of exposing adenocarcinoma cells to vitamin C/vitamin E (VC/VE) combinations as a means to reduce toxicity […]
Hepatic Oval Cells: A Potential Source of Cartilage
Chris Meinhart and Dr. Laura C Bridgewater, Microbiology Damage to articular cartilage found in synovial joints can occur both by trauma and disease processes. Cartilage, because of its avascular nature and low cellularity, has very poor regeneration capabilities. It is therefore important to explore new and effective cellular therapies to facilitate the repair of diseased […]
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