David Broadbent, Dr. Joshua Andersen, Department of Chemistry and Biochemistry The resistance of tumor cells to chemotherapy is a critical problem in the clinic and is a common cause of mortality in cancer. Emerging data suggests that resistance to chemotherapy is caused by a tumor-expressed protein called 14-3-3ζ, yet the mechanism to explain 14-3-3ζ-mediated chemoresistance […]
Search Results for: cancer
Dietary Prevention of Prostate Cancer in the TRAMP Mouse Model
Brett Shaw and Dr. Merrill Christensen, Department of Nutrition, Dietetics and Food Science Introduction This project utilized histology in determining whether dietary supplementation of selenium and/or isoflavones (a component of soy) had a preventative effect on the development of prostate cancer. Additionally, we explored the timing of introduction of these supplements and observed their individual […]
Subsequent Primary Malignancies in Survivors of Childhood Cancer
Emily Matson and Dr. Ray Merrill, Department of Health Science INTRODUCTION Although cancer is often considered a disease of old age, it kills more children ages 1 to 14 years in the United States than any other cause, except unintentional injuries [1]. Through advances in diagnosing and treating cancer, child survival of cancer has improved […]
The Role of Timing of Dietary Selenium and Isoflavone Supplementation in the Reduction of Prostate Cancer Risk Factors in TRAMP Mice
Ji Su Park and Dr. Merrill Christensen, Department of Nutrition, Dietetics, and Food Science Introduction Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer deaths in American men, with a predicted 29,720 deaths in 2013. (1) Previous studies have shown that both selenium (Se) and soy isoflavones reduce risk […]
Diagnostic and Therapeutic Potential of the Over-expression of Nucleotide Salvage Pathway Enzymes to the Plasma Membrane of Solid, Cancerous Tumors
Daniel Sharp and Dr. Kim O’Neill, MMBio Immunotherapy is a developing field in cancer treatment that relies upon the bodies natural defenses to target and eliminate cancerous cells. In order for the immune system to differentiate cancerous tissue from normal tissue there must be some mechanism for targeting only cancerous cells. Without a targeting mechanism, […]
Student Mentoring in Research: Laser-Activated Drug Delivery to Cancer Cells
William G. Pitt, Chemical Engineering Department Summary of Scope of Proposal This proposal was submitted in October of 2011 to organize and fund a mentoring group in the Pitt lab in Chemical Engineering. Marjan Javadi, then a PhD candidate in Chemical Engineering, and 5 uldergraduate students participated in this research group. The purpose was 2-‐fold, […]
Isolation And Structural Elucidation Of Cancer Therapeutic Agents In Rhamnaecae Ziziphus Obtusifolia
Matthew Woll and Dr. Noel Owen, Chemistry and Biochemistry Many important and useful biological compounds are found in plants. Extensive work has been done on evaluating anti-cancer 1, 2, anti-malarial 3, and anti-viral 4 properties of plants. The Yaqui Indians of northern Mexico have traditionally used many natural products to cure various diseases. Gloria Moroyoqui, […]
Perceptions of Somali Women on Cervical Cancer Screening
Alphaeus M. Wise and Dr. Barry L. Johnson, Sociology Somalis represent a growing group of new immigrants to Minnesota. Because of their recent immigration, there has been very little research done on their perceptions of Western medicine, in particular, preventive measures such as cervical cancer screenings. I became interested in this while working at a […]
Anticancer Extracts From Bark Of Sonoran Desert Plants
Kimberly Jo Davis and Dr. Rex G. Cates, Botany and Range Science There are many approaches to collecting medicinal plants. I compared results from two plant collection approaches, the ethnobotanical-based collection and ecologically-based collection. The ethnobotanical approach is based on plant use by native people. The ecological approach is based on plant life history principles […]
Bax Over-expression Coupled With Bcl-2 Suppression Under The Control of The Cancer-specific Thymidine Kinase Promoter
Brian H. Ladle and Dr. Kim L. O’Neill, Microbiology As researchers continue to discover the molecular origins of cancer, gene therapy targeting cellular processes gone awry shows great promise as the future in cancer treatment. Extensive research is being done to develop more effective techniques targeting different cellular events. One pathway receiving increased attention is […]
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