Professor David Busath, Physiology and Biophysics I was awarded a MEG in 2008 (with support continuing through 2009) for the project entitled “Biophysical Mechanism of Anesthetics.” The goals of the project were to measure the impact of volatile general anesthetics (isoflurane, sevoflurane, and desflurane) on: The axial rotation of fluorescent dyes that insert in different […]
Jak/Stat Pathway Utilized by Adrenal Cells in Response to IL-6
Brice Jason Williams and Dr. Allan M. Judd, Zoology In most mammals, the adrenal cortex produces the hormones cortisol, aldosterone, and dehydroepiandrosterone (DHEA). These hormones have profound effects upon water and salt balance, the inflammatory response, and the metabolism of sugars, fats, and proteins. Because of its importance in maintaining homeostasis, the body highly regulates […]
Effects of Dietary Phytoestrogens on Calcium-Binding Proteins and COX- 2 in the Frontal Cortex of Adult Rats
Lilyan Yi Tian and Dr. Edwin Lephart, Zoology Phytoestrogens are estrogen-like molecules found in many plants (that have a diphenolic, non-steroidal structure), such as, fruits, vegetables, legumes, whole-grain and especially soy products. These plant estrogen mimic the ability to selectively bind estrogen receptors and have recently received a great deal of investigative attention due to […]
Systematics and Genetic Variation Among the Cryptic Sub-Species Complex of Two- Lined Salamanders Eurycea bislineata
Eric Swenson and Dr. Keith Crandall, Zoology DNA sequence analysis can be a very powerful tool to examine the evolutionary history of many different species of organisms. One of the most useful benefits is determining species lineage and evolutionary relationships. In this study we attempted to examine the phylogenetic relationship of Eurycea bislineata, an east […]
Locating Chondrocyte-specific Enhancer Elements in the First Intronic Region of the Col11a2 Gene
Steven Alan Smith and Dr. Laura Bridgewater, Zoology Osteoarthritis is one of most prominent illnesses that plague our world today. It involves the degeneration of cartilage between joints due to a reduction of collagen fibrils. The type XI collagen gene (Col11a2) is one of a few genes responsible for the production of the collagen fibrils. […]
The Separation of Suspected Subspecies of Cutthroat Trout Using Mitochondrial DNA Sequences
Becky A. Shiozawa and Professor R. Paul Evans, Zoology Current mitochondrial DNA techniques using restriction fragment length polymorphisms (RFLPs) are still unsuccessful in determining phylogenetic relationships between subspecies of cutthroat trout (Oncorhynchus clarki), such as the relationships between Snake River finespot cutthroat trout and Yellowstone cutthroat trout, Bear River Bonneville cutthroat trout and Yellowstone cutthroat […]
Premature Onset of Osteoarthritis Due to a Col11a1 Gene Mutation
Victoria Ryder and Dr. Robert Seegmiller, Zoology Introduction Cartilage collagen mutations can alter the load-bearing properties of articular cartilage (AC), possibly leading to premature osteoarthritis. AC consists mainly of types II, VI, IX, X, and XI collagen.1 Collagen fibrils in AC are heteropolymers of types II, IX, and XI collagen2. Type II is the major […]
Histology: A Student’s Comprehensive Lab Manual and Corresponding CD
Jon Christopher Kerr and Dr. Richard A. Heckmann, Zoology The purpose of this project was to provide a comprehensive and accurate text for the study of histology–the microscopic study of cells and tissues. In order to facilitate this study, appropriate text corresponding to over 400 histological images was prepared. This manual explains the images, defines […]
Examination of AP-4 as a Transcriptional Activator of the Col11a2 Chondrocyte-specific Enhancer Elements
Todd Lincoln Jackson and Dr. Laura Bridgewater, Zoology Purpose My purpose is to explore activator protein 4’s (AP-4) role in the expression of the Col11a2 gene. My hypothesis is that AP-4 will bind to the Col11a2 enhancer elements and increase activity of that gene. AP-4 is a ubiquitous transcription factor. Transcription factors are proteins that […]
Identification of the Activator Proteins for the DNA-Protein Interaction of a Primary Cartilage Enhancer
L. Daniel Holsinger and Dr. Laura Bridgewater, Zoology Abstract: The Human col11 2 gene is responsible for the production of type XI collagen, one of the three components of the collagen triple helix. Disruption of this gene results in varied problems including dwarfism, osteoarthritis and possibly cleft palate. In order to understand more about this […]
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